Imipramine Antibody (052): sc-57878

Imipramine Antibody (052) is a mouse monoclonal IgG2b antibody that detects the Imipramine protein of non-species reactive by enzyme-linked immunosorbent assay (ELISA). Anti-Imipramine antibody (052) is available as a non-conjugated format, specifically designed to facilitate research into the therapeutic effects and mechanisms of Imipramine, a tricyclic antidepressant belonging to the dibenzazepine group. Imipramine plays a crucial role in the treatment of clinical depression and enuresis, primarily by inhibiting the reuptake of serotonin, which is essential for mood regulation. This inhibition is particularly significant as serotonin availability increases in the synaptic cleft, thereby improving mood and emotional stability in patients. With a molecular weight of 280.407 g/mol, Imipramine is metabolized in the body to desipramine, which further contributes to antidepressant effects. Using Imipramine can lead to various side effects, including tremors, dry mouth, blurred vision, and potential cardiac and neurological disturbances in cases of overdose. Anti-Imipramine antibody (052) allows researchers to explore these effects and underlying mechanisms of action, providing valuable insights into the pharmacological properties of this important therapeutic agent.

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Imipramine Antibody (052) References:

1. Clinical evidence of an interaction between imipramine and acetylsalicylic acid on protein binding in depressed patients.  |  Juárez-Olguín, H., et al. 2002. Clin Neuropharmacol. 25: 32-6. PMID: 11852294
2. Imipramine N-glucuronidation in human liver microsomes: biphasic kinetics and characterization of UDP-glucuronosyltransferase isoforms.  |  Nakajima, M., et al. 2002. Drug Metab Dispos. 30: 636-42. PMID: 12019188
3. Acrocyanosis as a side effect of tricyclic antidepressants: a case report.  |  Karakaya, I., et al. 2003. Turk J Pediatr. 45: 155-7. PMID: 12921305
4. Control of enuresis with imipramine.  |  MARGOLIS, LH. 1962. Am J Psychiatry. 119: 269-70. PMID: 14469783
5. In vitro microsomal metabolism of imipramine under conditions mimicking the in vivo steady-state situation.  |  Linnet, K. 2004. Hum Psychopharmacol. 19: 31-6. PMID: 14716709
6. Switching from imipramine to sertraline in panic disorder.  |  Mavissakalian, MR. 2004. J Psychiatr Pract. 10: 88-94. PMID: 15330404
7. Differential effect of imipramine and related compounds on Mg2+ efflux from rat erythrocytes.  |  Ebel, H., et al. 2004. Biochim Biophys Acta. 1667: 132-40. PMID: 15581848
8. Tritiation of imipramine and pseudo irreversible analogues 3-cyanoimipramine and 2-nitroimipramine at high specific activity.  |  Ahern, DG., et al. 2006. Appl Radiat Isot. 64: 798-801. PMID: 16556503