Ichthammol (CAS 8029-68-3)

Ichthammol, derived from shale oil, is a complex mixture of organic compounds, primarily composed of sulfonated hydrocarbons. In research, its anti-inflammatory and antimicrobial properties have garnered interest, particularly in dermatology and wound healing studies. Its mechanism of action is attributed to several factors, including its ability to reduce inflammation by inhibiting the release of pro-inflammatory cytokines and mediators, such as tumor necrosis factor-alpha (TNF-α) and interleukins. Additionally, ichthammol has been found to possess antimicrobial activity against a wide range of bacteria and fungi, making it a potential candidate for topical applications in the treatment of skin infections and wounds. Research has also explored its role in promoting wound healing by stimulating the proliferation and migration of fibroblasts and keratinocytes, crucial cells involved in tissue repair. Furthermore, ichthammol's antioxidant properties have been investigated for their potential in protecting skin cells from oxidative stress-induced damage, highlighting its versatile applications in dermatological research aimed at addressing various skin conditions and wound healing processes.