Exenatide acetate (CAS 141732-76-5)
Alternate Names:
Exendin-4
CAS Number:
141732-76-5
Molecular Weight:
4246.62
Molecular Formula:
C184H282N50O60S•C2H4O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Exenatide Acetate is a synthetic peptide that is a chemically modified form of exenatide, which can be found in the Salivary Gland Extract of the Gila Monster, scientifically known as Heloderma suspectum. The peptide structure of exenatide acetate consists of a sequence of amino acids that closely resembles that of the human incretin hormone glucagon-like peptide-1 (GLP-1), which is involved in glucose metabolism. In biochemical research, exenatide acetate serves as useful for studying the GLP-1 receptor and its role in glucose homeostasis. Additionally, it interacts with other receptors such as the glucagon receptor and triggers the cAMP-dependent protein kinase A pathway.
Exenatide acetate (CAS 141732-76-5) References
- In vitro and in vivo sustained release of exenatide from vesicular phospholipid gels for type II diabetes. | Zhang, Y., et al. 2016. Drug Dev Ind Pharm. 42: 1042-9. PMID: 26558908
- Long-Acting Phospholipid Gel of Exenatide for Long-Term Therapy of Type II Diabetes. | Hu, M., et al. 2016. Pharm Res. 33: 1318-26. PMID: 26857900
- In vivo evaluation of an oral self-emulsifying drug delivery system (SEDDS) for exenatide. | Menzel, C., et al. 2018. J Control Release. 277: 165-172. PMID: 29574041
- Primary and Secondary Binding of Exenatide to Liposomes. | Stulz, A., et al. 2020. Biophys J. 118: 600-611. PMID: 31972156
- Targeted nanoparticles towards increased L cell stimulation as a strategy to improve oral peptide delivery in incretin-based diabetes treatment. | Xu, Y., et al. 2020. Biomaterials. 255: 120209. PMID: 32580098
- Ultra-sensitive bioanalysis of the therapeutic peptide exenatide for accurate pharmacokinetic analyses at effective plasma concentrations utilizing UPLC-MS/MS. | Sauter, M., et al. 2020. J Pharm Anal. 10: 233-239. PMID: 32612869
- The Effect of Counterions in Hydrophobic Ion Pairs on Oral Bioavailability of Exenatide. | Phan, TNQ., et al. 2020. ACS Biomater Sci Eng. 6: 5032-5039. PMID: 33455296
- Prolonged activity of exenatide: Detailed comparison of Site-specific linear polyglycerol- and poly(ethylene glycol)-conjugates. | Tully, M., et al. 2021. Eur J Pharm Biopharm. 164: 105-113. PMID: 33957224
- GLP-1R activation ameliorated novel-object recognition memory dysfunction via regulating hippocampal AMPK/NF-κB pathway in neuropathic pain mice. | Zhang, LQ., et al. 2021. Neurobiol Learn Mem. 182: 107463. PMID: 34015440
- Characterization of the physicochemical interactions between exenatide and two intestinal permeation enhancers: Sodium caprate (C10) and salcaprozate sodium (SNAC). | Twarog, C., et al. 2022. Int J Pharm. 626: 122131. PMID: 36028084
- Recent Progress in Microencapsulation of Active Peptides-Wall Material, Preparation, and Application: A Review. | Li, M., et al. 2023. Foods. 12: PMID: 36832971
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Exenatide acetate, 1 mg | sc-499140 | 1 mg | $388.00 |