ERM Antibody (3H3): sc-293164
- ERM Antibody (3H3) is a mouse monoclonal IgG1 provided at 100 µg/ml
- raised against recombinant protein fragment corresponding to ERM of human origin
- recommended for detection of ERM of mouse, rat and human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for ERM Antibody (3H3). This work is in progress.
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ERM Antibody (3H3) is a mouse monoclonal IgG1 antibody that detects ERM in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). ERM, or Ezrin-Radixin-Moesin, plays a crucial role in linking the plasma membrane to the cytoskeleton, thereby influencing cell shape, motility, and signaling pathways. Anti-ERM antibody (3H3) targets a protein predominantly located at the cell membrane that′s essential for the formation of microvilli and membrane ruffles, which are vital for processes such as cell adhesion and migration. The proper localization of ERM is critical for maintaining cellular architecture and facilitating communication between the extracellular environment and the cell′s interior. ERM monoclonal antibody (3H3) enables detection of a protein involved in various cellular functions, including the regulation of cell growth and differentiation, making ERM a significant player in both normal physiology and disease states, such as cancer metastasis. ERM (3H3) antibody provides reliable detection and quantification of ERM, enabling researchers to explore its diverse roles in cellular dynamics and pathology.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
ERM Antibody (3H3) References:
- ERM proteins in cell adhesion and membrane dynamics. | Mangeat, P., et al. 1999. Trends Cell Biol. 9: 187-92. PMID: 10322453
- ERM-Merlin and EBP50 protein families in plasma membrane organization and function. | Bretscher, A., et al. 2000. Annu Rev Cell Dev Biol. 16: 113-43. PMID: 11031232
- ERM proteins in epithelial cell organization and functions. | Fiévet, B., et al. 2007. Biochim Biophys Acta. 1773: 653-60. PMID: 16904765
- Merlin and the ERM proteins--regulators of receptor distribution and signaling at the cell cortex. | McClatchey, AI. and Fehon, RG. 2009. Trends Cell Biol. 19: 198-206. PMID: 19345106
- Emerging role for ERM proteins in cell adhesion and migration. | Arpin, M., et al. 2011. Cell Adh Migr. 5: 199-206. PMID: 21343695
- Physiological Roles of ERM Proteins and Transcriptional Regulators in Supporting Membrane Expression of Efflux Transporters as Factors of Drug Resistance in Cancer. | Ogihara, T., et al. 2020. Cancers (Basel). 12: PMID: 33198344
- Effector-mediated ERM activation locally inhibits RhoA activity to shape the apical cell domain. | Zaman, R., et al. 2021. J Cell Biol. 220: PMID: 33836044
- The ERM protein moesin regulates natural killer cell homeostasis in vivo. | Satooka, H., et al. 2022. Cell Immunol. 371: 104456. PMID: 34798556
- Structural insights into the mechanism of overcoming Erm-mediated resistance by macrolides acting together with hygromycin-A. | Chen, CW., et al. 2023. Nat Commun. 14: 4196. PMID: 37452045
- Cooperative polarization of MCAM/CD146 and ERM family proteins in melanoma. | Miller, SG., et al. 2024. Mol Biol Cell. 35: ar31. PMID: 38117590
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ERM Antibody (3H3) | sc-293164 | 100 µg/ml | $322.00 |