Dasatinib (monohydrate) (CAS 863127-77-9)
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Dasatinib monohydrate is a compound extensively utilized in various research areas, particularly those focusing on cellular signaling and oncogenesis. It is known for its inhibitory effects on a range of tyrosine kinases, including BCR-ABL and SRC family kinases. This inhibition is significant in studies related to the signaling pathways that drive cell proliferation and survival. Researchers utilize dasatinib monohydrate to dissect the molecular events in cells that contribute to the development and progression of certain diseases. In addition, it′s used in studies to understand the mechanisms of resistance that can develop with kinase inhibitors. The compound is also valuable in the field of chemobiology to explore the interactions between small molecules and their protein targets. Furthermore, dasatinib monohydrate is instrumental in investigating the broader biological consequences of tyrosine kinase inhibition in cellular models.
Dasatinib (monohydrate) (CAS 863127-77-9) References
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- Interaction of the efflux transporters ABCB1 and ABCG2 with imatinib, nilotinib, and dasatinib. | Eadie, LN., et al. 2014. Clin Pharmacol Ther. 95: 294-306. PMID: 24107928
- Dasatinib, large granular lymphocytosis, and pleural effusion: useful or adverse effect? | Paydas, S. 2014. Crit Rev Oncol Hematol. 89: 242-7. PMID: 24210599
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- Harnessing the therapeutic potential of anticancer drugs through amorphous solid dispersions. | Gala, UH., et al. 2020. Biochim Biophys Acta Rev Cancer. 1873: 188319. PMID: 31678141
- Indocyanine green-labeled dasatinib as a new fluorescent probe for molecular imaging of gastrointestinal stromal tumors. | Fujimoto, S., et al. 2021. J Gastroenterol Hepatol. 36: 1253-1262. PMID: 32989784
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Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Dasatinib (monohydrate), 10 mg | sc-218081 | 10 mg | $94.00 | |||
Dasatinib (monohydrate), 100 mg | sc-218081A | 100 mg | $364.00 |