CD4 Antibody (YTA 3.1.2): sc-53838

CD4 Antibody (YTA 3.1.2) is a rat monoclonal IgG2b antibody developed to recognize the CD4 protein, also known as T4 or Leu-3, on mouse T cells. Anti-CD4 antibody (YTA 3.1.2) targets an epitope generated against concanavalin A (Con-A)-activated splenocytes of mouse origin, enabling effective detection of the CD4 T4/Leu-3 antigen through immunofluorescence (IF) and flow cytometry (FCM). CD4 is a membrane glycoprotein composed of four extracellular immunoglobulin-like domains, playing a crucial role in the immune system by serving as a co-receptor for the T cell receptor (TCR). CD4 interacts with major histocompatibility complex class II (MHC II) molecules on antigen-presenting cells, enhancing the TCR′s ability to recognize and bind to antigens. CD4 associates with the tyrosine kinase Lck, which is essential for initiating T cell activation and signal transduction upon antigen recognition. These interactions between CD4 and proteins such as MHC II and Lck are fundamental for effective T helper cell responses, including cytokine production and cell proliferation. CD4 is involved in the formation of the immunological synapse, a specialized contact point between T cells and antigen-presenting cells that facilitates precise communication and activation. CD4 monoclonal antibody (YTA 3.1.2) serves as an invaluable tool for researchers studying T cell biology, immune response mechanisms, and related diseases, providing insights into the interactions and functions of CD4 in various cellular contexts.

The preferred CD4 antibody is CD4 Antibody (GK1.5): sc-13573.