CD4 Antibody (B486A1): sc-32811

CD4 Antibody (B486A1) is a mouse monoclonal IgG1 kappa light chain antibody engineered to detect CD4, also known as T4 or Leu 3, in human samples. Raised against recombinant human CD4, anti-CD4 antibody (B486A1) is recommended for use in western blotting (WB), immunofluorescence (IF), and flow cytometry (FCM) applications, ensuring reliable detection across various experimental settings. CD4 is a membrane-bound glycoprotein prominently expressed on the surface of T helper cells, as well as on cortical cells, mature medullary thymocytes, microglial cells, and dendritic cells. Located on the cell membrane, CD4 plays a pivotal role in the immune system by acting as a co-receptor for the T cell receptor (TCR), enhancing the interaction between TCRs and class II major histocompatibility complex (MHC) molecules on antigen-presenting cells. This interaction is essential for effective T cell activation and the initiation of adaptive immune responses. The cell surface localization of CD4 facilitates interaction with extracellular ligands and signaling molecules, which is crucial for T cell function and communication within the immune system. Additionally, CD4 serves as the primary receptor for the human immunodeficiency virus (HIV), mediating viral entry into host cells and contributing to immune system impairment in HIV-infected individuals. By enabling precise identification and characterization of CD4-expressing cells, CD4 monoclonal antibody (B486A1) supports critical research in immunology, including studies on autoimmune diseases, infectious diseases, and the development of immunotherapies.

The preferred CD4 antibody is CD4 Antibody (GK1.5): sc-13573.