Uteroglobin/SCGB1A1/CC10 Antibody (98-G): sc-130411

CC10 Antibody (98-G) is a mouse monoclonal IgG2b antibody that detects Clara cell 10 (CC10) in human samples through applications such as immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). CC10 is a crucial phospholipase A2 inhibitor that plays a significant role in modulating inflammation within the airway passages, making CC10 particularly important in respiratory conditions like asthma. CC10 is predominantly expressed in nonciliated airway epithelial cells of the lung and is also found in urogenital secretions, highlighting CC10′s relevance in both respiratory and reproductive health. Notably, CC10 expression is regulated by various transcription factors, including AP-1 and hepatocyte nuclear factor-3, and CC10 levels fluctuate in relation to the ovarian menstrual cycle, with progesterone potentially stimulating CC10 expression in the human endometrium. CC10′s ability to inhibit matrix metalloproteinases, such as MMP-2 and MMP-9, has been demonstrated in studies involving non-small cell lung cancer cell lines, where CC10 overexpression resulted in reduced invasiveness, suggesting that loss of CC10 may contribute to carcinogenesis. With multifaceted roles in inflammation and cancer biology, anti-CC10 antibody (98-G) serves as a valuable tool for researchers investigating the underlying mechanisms of these critical physiological processes.

The preferred Uteroglobin/SCGB1A1/CC10 antibody is Uteroglobin/SCGB1A1/CC10 Antibody (E-11): sc-365992.