Molecular structure of CAY10576, CAS Number: 862812-98-4
CAY10576 (CAS 862812-98-4)
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Alternate Names:
IKK-3 Inhibitor IX
Application:
CAY10576 is a thiophenecarbonitrile compound that acts as a potent ATP-competitive inhibitor of IKK-3
CAS Number:
862812-98-4
Purity:
≥95%
Molecular Weight:
469.53
Molecular Formula:
C22H19N3O5S2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
CAY10576 is a chemically synthesized thiophenecarbonitrile derivative characterized by its potent inhibitory activity against IKK-3 (also known as IKK-epsilon), with an IC50 value of 40 nM. This compound operates through an ATP-competitive mechanism, effectively blocking the ATP binding site of IKK-3, a kinase involved in the regulation of inflammatory responses and immune function. Its high specificity is highlighted by its approximately 20-fold selectivity towards inhibiting IKK-3 over Polo-like kinase 1 (PLK1), and more than 125-fold selectivity over a panel of nine other kinases, including IKK-1 and IKK-2 (IKK-alpha/beta), which are pivotal in NF-κB signaling pathway and immune response modulation.
CAY10576 (CAS 862812-98-4) References
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- Abstracts of the 72nd Scientific Sessions of the American Diabetes Association. June 8-12, 2012. Philadelphia, Pennsylvania, USA. | . 2012. Diabetes. 61 Suppl 1: A1-722. PMID: 22701883
- Coordinate direct input of both KRAS and IGF1 receptor to activation of PI3 kinase in KRAS-mutant lung cancer. | Molina-Arcas, M., et al. 2013. Cancer Discov. 3: 548-63. PMID: 23454899
- Inflammation produces catecholamine resistance in obesity via activation of PDE3B by the protein kinases IKKε and TBK1. | Mowers, J., et al. 2013. Elife. 2: e01119. PMID: 24368730
- The Baf60c/Deptor pathway links skeletal muscle inflammation to glucose homeostasis in obesity. | Meng, ZX., et al. 2014. Diabetes. 63: 1533-45. PMID: 24458360
- Injury-induced MRP8/MRP14 stimulates IP-10/CXCL10 in monocytes/macrophages. | Wang, J., et al. 2015. FASEB J. 29: 250-62. PMID: 25342131
- ZBP-89 reduces histone deacetylase 3 by degrading IkappaB in the presence of Pin1. | Ye, CG., et al. 2015. J Transl Med. 13: 23. PMID: 25623232
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- E3-ubiquitin ligase TRIM6 aggravates myocardial ischemia/reperfusion injury via promoting STAT1-dependent cardiomyocyte apoptosis. | Zeng, G., et al. 2019. Aging (Albany NY). 11: 3536-3550. PMID: 31171760
- IKBKE activity enhances AR levels in advanced prostate cancer via modulation of the Hippo pathway. | Bainbridge, A., et al. 2020. Nucleic Acids Res. 48: 5366-5382. PMID: 32324216
- Small Extracellular Vesicles Have GST Activity and Ameliorate Senescence-Related Tissue Damage. | Fafián-Labora, JA., et al. 2020. Cell Metab. 32: 71-86.e5. PMID: 32574561
- IκB kinase-ε-mediated phosphorylation triggers IRF-1 degradation in breast cancer cells. | Remoli, AL., et al. 2020. Neoplasia. 22: 459-469. PMID: 32784074
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- Comprehensive Pan-Cancer Analysis of the Prognostic and Immunological Roles of the METTL3/lncRNA-SNHG1/miRNA-140-3p/UBE2C Axis. | Jiang, X., et al. 2021. Front Cell Dev Biol. 9: 765772. PMID: 34858987
- A high-throughput 384-well CometChip platform reveals a role for 3-methyladenine in the cellular response to etoposide-induced DNA damage. | Li, J., et al. 2022. NAR Genom Bioinform. 4: lqac065. PMID: 36110898
Inhibitor of:
IKK.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CAY10576, 1 mg | sc-223870 | 1 mg | $92.00 | |||
CAY10576, 5 mg | sc-223870A | 5 mg | $361.00 |