Ambroxol hydrochloride CAS: 23828-92-4
MF: C13H18Br2N2O•HCl
MW: 414.6
An expectorant antioxidant and antiinflammatory agent.

Ambroxol hydrochloride (CAS 23828-92-4)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 133ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Solicitud: An expectorant antioxidant and antiinflammatory agent
Número de CAS: 23828-92-4
Pureza: 98%
Peso Molecular: 414.6
Fórmula Molecular: C13H18Br2N2O•HCl
* En el Certificado de Análisis específico de lote, puede encontrar información específica (como el contenido en agua).
Envíe una reseña para este producto y reciba 15 créditos Cruz

Ambroxol hydrochloride is a small molecule expectorant and mucolytic agent with antioxidant and antiinflammatory effects. Ambroxol stimulates the secretion of surfactant which decreases mucus adhesion to the bronchial lining and produces expectorant effects. The antioxidant effects of Ambroxol are well demonstrated, where lipid peroxidation initiated by t-butyl hydroperoxide or doxorubicin is suppressed in the presence Ambroxol, and scavenging of hydroxyl radicals and cellular superoxide radical anions is also observed. Ambroxol produces antiinflammatory effects by blocking the expression of proinflammatory messengers, inhibiting the release of histamine from mast cells and the generation of cytokines and interleukins. Ambroxol hydrochloride is an inhibitor of Sodium Channel Protein.


References

1. Disse, B.G. 1987. Eur J Respir Dis Suppl. 153: 255-262. PMID: 3322865
2. Wilke, A., et al. 1987. Respiration. 52: 129-136. PMID: 3671891
3. Nowak, D., et al. 1995. Free Radic. Biol. Med. 19: 659-663. PMID: 8529925
4. Gibbs, B.F., et al. 1999. Inflamm. Res. 48: 86-93. PMID: 10202994
5. Stetinová, V., et al. 2004. Clin. Exp. Med. 4: 152-158. PMID: 15599665
6. Laurent, A., et al. 2004. Hepatology. 39: 1277-1285. PMID: 15122756
7. Su, X., et al. 2004. Intensive Care Med. 30: 133-140. PMID: 14504727
8. Beeh, K.M., et al. 2008. Eur. J. Med. Res. 13: 557-562. PMID: 19073395
9. Malerba, M., 2008. Expert Opin Drug Metab Toxicol. 4: 1119-1129. PMID: 18680446

Apariencia :
Crystalline powder
Estado de Materia :
Solid
Solubilidad :
Soluble in methanol, water (~5 mg/ml), ethanol (~5 mg/ml), and DMSO (50 mM). Insoluble in ether.
ALMACENAMIENTO :
Store at 4° C
Punto de Fusión :
>235° C (dec.)
IC50 :
tetrodotoxin (TTX)-resistant channels: IC50 = 35.2 µM; TTX-sensitive subtypes: IC50 = 111.5 µM
Valores de pK :
pKb: 8.69
Para Uso Exclusivo en Investigación. No está diseñado para uso en diagnosis o terapia.
WGK Alemania :
3
RTECS :
GV8423000
PubChem CID :
108013
Indice de Merck :
14: 386
Número MDL :
MFCD00078932
Número EC :
242-500-3
SMILES :
C1CC(CCC1NCC2=CC(=CC(=C2N)Br)Br)O.Cl

Descargar SDS (MSDS)

CERTIFICADO DE ANÁLISIS

Necesita Adobe Acrobat Reader para ver de forma fiable,
imprimir y comentar el documento de PDF

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 131ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 9ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

Santa Cruz Biotechnology, Inc. es un líder mundial en el desarrollo de productos para el mercado de la investigación biomédica. Llámenos gratis al 00 800 4573 8000.
Copyright © 2007-2020 Santa Cruz Biotechnology, Inc. All Rights Reserved."Santa Cruz Biotechnology", y el logo de Santa Cruz Biotechnology, Inc., "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", el logo de San Juan Ranch, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", y "EZ Touch" son marcas registradas de Santa Cruz Biotechnology, Inc. Todas las marcas registradas son propiedad de su respectivo dueño.