Molecular structure of 8-pCPT-2′-O-Me-cAMP, CAS Number: 634207-53-7
8-pCPT-2′-O-Me-cAMP (CAS 634207-53-7)
See product citations (5)
Alternate Names:
8-(4-Chlorophenylthio)-2′-O-methyladenosine 3′,5′-cyclic monophosphate monosodium
Application:
8-pCPT-2′-O-Me-cAMP is a potent membrane activator of guanine nucleotide exchange factor, Epac
CAS Number:
634207-53-7
Purity:
≥98%
Molecular Weight:
507.82
Molecular Formula:
C17H16N5O6ClPS•Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
8-pCPT-2′-O-Me-cAMP is an analog of cAMP which is a specific and potent membrane activator of guanine nucleotide exchange factor, Epac, but does not have any effects on PKA. 8-pCPT-2′-O-Me-cAMP can be used to stimulate the release of calcium from intracellular calcium stores and exocytosis in beta cells and the insulin-secreting cell line (INS-1). Studies indicate that substitution of a 2′-methoxyl group in place of the 2′-hydroxyl group of cAMP results in the specificity of the compound towards Epac. Epac2, another guanine nucleotide exchange factor, can inhibit the effects of 8-pCPT-2′-O-Me-cAMP. Furthermore, 8-pCPT-2′-O-Me-cAMP can be useful as a pharmacological tool, analyzing PKA-independent signaling properties of cAMP.
8-pCPT-2′-O-Me-cAMP (CAS 634207-53-7) References
- A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK. | Enserink, JM., et al. 2002. Nat Cell Biol. 4: 901-6. PMID: 12402047
- Epac-selective cAMP analog 8-pCPT-2'-O-Me-cAMP as a stimulus for Ca2+-induced Ca2+ release and exocytosis in pancreatic beta-cells. | Kang, G., et al. 2003. J Biol Chem. 278: 8279-85. PMID: 12496249
- Epac-1 activator 8-O-cAMP augments renoprotective effects of syngeneic [corrected] murine EPCs in acute ischemic kidney injury. | Patschan, D., et al. 2010. Am J Physiol Renal Physiol. 298: F78-85. PMID: 19906949
- Epac1 mediates protein kinase A-independent mechanism of forskolin-activated intestinal chloride secretion. | Hoque, KM., et al. 2010. J Gen Physiol. 135: 43-58. PMID: 20038525
- 8-pCPT-conjugated cyclic AMP analogs exert thromboxane receptor antagonistic properties. | Sand, C., et al. 2010. Thromb Haemost. 103: 662-78. PMID: 20135060
- Epac-Rap signaling reduces cellular stress and ischemia-induced kidney failure. | Stokman, G., et al. 2011. J Am Soc Nephrol. 22: 859-72. PMID: 21493776
- cAMP signalling protects proximal tubular epithelial cells from cisplatin-induced apoptosis via activation of Epac. | Qin, Y., et al. 2012. Br J Pharmacol. 165: 1137-50. PMID: 21745194
- Off-target effect of the Epac agonist 8-pCPT-2'-O-Me-cAMP on P2Y12 receptors in blood platelets. | Herfindal, L., et al. 2013. Biochem Biophys Res Commun. 437: 603-8. PMID: 23850619
- PKA and Epac activation mediates cAMP-induced vasorelaxation by increasing endothelial NO production. | García-Morales, V., et al. 2014. Vascul Pharmacol. 60: 95-101. PMID: 24469067
- Epac-Rap signaling reduces oxidative stress in the tubular epithelium. | Stokman, G., et al. 2014. J Am Soc Nephrol. 25: 1474-85. PMID: 24511123
- Cyclic AMP pathway modifies memory through neural cell adhesion molecule alterations in the rat hippocampus. | Razmi, A., et al. 2014. Acta Med Iran. 52: 246-55. PMID: 24901853
- Actions of cAMP on calcium sensitization in human detrusor smooth muscle contraction. | Hayashi, M., et al. 2016. BJU Int. 117: 179-91. PMID: 25981809
- Role of PI3K/Akt and MEK/ERK Signalling in cAMP/Epac-Mediated Endothelial Barrier Stabilisation. | Gündüz, D., et al. 2019. Front Physiol. 10: 1387. PMID: 31787905
- Epac activation ameliorates tubulointerstitial inflammation in diabetic nephropathy. | Yang, WX., et al. 2022. Acta Pharmacol Sin. 43: 659-671. PMID: 34103688
Inhibitor of:
Olfr438.Activator of:
α-protein kinase 3, βPIX, AKAP 10, ARHGAP23, C11orf74, CLLD6, Ect2, Epac, FAM118A, FAM83E, GRK 5, LAGE-3, MKS3, NHEDC1, Olfr473, Olfr474, Olfr476, Olfr584, Olfr585, Olfr586, Olfr702, Olfr868, RAP1, RGL4, Vmn1r167, and WDR18.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
8-pCPT-2′-O-Me-cAMP, 1 mg | sc-257020 | 1 mg | $306.00 |