7Z,10Z,13Z,16Z,19Z-Docosapentaenoic acid CAS: 24880-45-3
MF: C22H34O2
MW: 330.50
A fatty acid shown to inhibit platelet aggregation.

7Z,10Z,13Z,16Z,19Z-Docosapentaenoic acid (CAS 24880-45-3)

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Sinónimo: Docosapentaenoic acid
Solicitud: A fatty acid shown to inhibit platelet aggregation
Número de CAS: 24880-45-3
Pureza: ≥98%
Peso Molecular: 330.50
Fórmula Molecular: C22H34O2
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Docosa-7Z,10Z,13Z,16Z,19Z-pentaenoic Acid (22:5, n-3), also known as DPA, is a fatty acid derived from fish oils that potently inhibits platelet aggregation. DPA has been reported to block the cyclooxygenase pathway and stimulate the lipoxygenase pathway, which results in effective platelet aggregation inhibition. Peripheral blood mononuclear cell research demonstrates that DPA diminishes cyclooxygenase-2 levels intracellularly and inhibits pro-inflammatory prostaglandin E2 production. Studies indicate that the compound plays an important role in the cubic membrane formation of mitochondria found in amoeba Chaos.


References

1. Akiba, S., et al. 2000. Biol. Pharm. Bull. 23: 1293-1297. PMID: 11085354
2. Rissanen, T., et al. 2000. Circulation. 102: 2677-2679. PMID: 11094031
3. Deng, Y., et al. 2009. FASEB J. 23: 2866-2871. PMID: 19406841
4. Nauroth, J.M., et al. 2010. Lipids. 45: 375-384. PMID: 20364438
5. Kaur, G., et al. 2011. Prog. Lipid Res. 50: 28-34. PMID: 20655949

Apariencia :
Oil
Estado de Materia :
Liquid
Solubilidad :
Soluble in ethanol, hexane, methylene chloride, 0.1M Na2CO3 (1.7 mg/ml), water (1.7 mg/ml) at 25° C, DMSO (~100 mg/ml), and DMF (~100 mg/ml).
ALMACENAMIENTO :
Store at -20° C
Indice de Refracción :
n20D 1.51
IC50 :
Cytochrome P450 19A1: IC50 = 16.8 µM (human)
Valores de pK :
pKa: 4.76
Para Uso Exclusivo en Investigación. No está diseñado para uso en diagnosis o terapia.
WGK Alemania :
2
RTECS :
JR1320000
PubChem CID :
5497182
Número MDL :
MFCD00156103
SMILES :
CC/C=C\\C/C=C\\C/C=C\\C/C=C\\C/C=C\\CCCCCC(=O)O

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