Molecular structure of 4,4′-Dimethoxychalcone, CAS Number: 2373-89-9
4,4′-Dimethoxychalcone (CAS 2373-89-9)
CAS Number:
2373-89-9
Molecular Weight:
268.31
Molecular Formula:
C17H16O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
4,4′-Dimethoxychalcone (4,4′-DMC) is a naturally occurring compound derived from chalcone, a molecule found in plants. It is hypothesized that 4,4′-Dimethoxychalcone functions by binding to specific receptors within the body, such as the estrogen receptor, the androgen receptor, and the PPARγ receptor. It is also believed to interact with various signaling pathways, such as the MAPK pathway, the PI3K/Akt pathway, and the NF-κB pathway. Furthermore, 4,4′-Dimethoxychalcone has demonstrated inhibitory effects on enzymes like 5-lipoxygenase and cyclooxygenase.
4,4′-Dimethoxychalcone (CAS 2373-89-9) References
- The flavonoid 4,4'-dimethoxychalcone promotes autophagy-dependent longevity across species. | Carmona-Gutierrez, D., et al. 2019. Nat Commun. 10: 651. PMID: 30783116
- Targeting GATA transcription factors - a novel strategy for anti-aging interventions? | Zimmermann, A., et al. 2019. Microb Cell. 6: 212-216. PMID: 31114793
- 4,4'Dimethoxychalcone: a natural flavonoid that promotes health through autophagy-dependent and -independent effects. | Zimmermann, A., et al. 2019. Autophagy. 15: 1662-1664. PMID: 31248332
- Mitochondrial permeability with autophagy in lifespan shortening: a novel therapeutic target for aging. | Yao, H., et al. 2019. Acta Biochim Biophys Sin (Shanghai).. PMID: 31680147
- A discovery platform for the identification of caloric restriction mimetics with broad health-improving effects. | Kepp, O., et al. 2020. Autophagy. 16: 188-189. PMID: 31690168
- AKT as a therapeutic target for autophagy induction and cancer therapy. | Wu, Q., et al. 2021. Oncoscience. 8: 34-36. PMID: 33884283
- Trojan Horse Delivery of 4,4'-Dimethoxychalcone for Parkinsonian Neuroprotection. | Zhang, W., et al. 2021. Adv Sci (Weinh). 8: 2004555. PMID: 33977069
- 4,4'-Dimethoxychalcone regulates redox homeostasis by targeting riboflavin metabolism in Parkinson's disease therapy. | Gong, J., et al. 2021. Free Radic Biol Med. 174: 40-56. PMID: 34332078
- Flavonoid 4,4'-dimethoxychalcone suppresses cell proliferation via dehydrogenase inhibition and oxidative stress aggravation. | Yang, C., et al. 2021. Free Radic Biol Med. 175: 206-215. PMID: 34506903
- 4,4'-dimethoxychalcone increases resistance of mouse oocytes to postovulatory aging in vitro. | Liu, L., et al. 2022. Reprod Biomed Online. 44: 411-422. PMID: 35153143
- 4,4'-Dimethoxychalcone protects the skin from AAPH-induced senescence and UVB-induced photoaging by activating autophagy. | Gu, Y., et al. 2022. Food Funct. 13: 4114-4129. PMID: 35316314
- Flavonoid 4,4'-dimethoxychalcone induced ferroptosis in cancer cells by synergistically activating Keap1/Nrf2/HMOX1 pathway and inhibiting FECH. | Yang, C., et al. 2022. Free Radic Biol Med. 188: 14-23. PMID: 35697292
- Metabolomics study of flavonoids in Coreopsis tinctoria of different origins by UPLC-MS/MS. | Wang, Y., et al. 2022. PeerJ. 10: e14580. PMID: 36570002
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
4,4′-Dimethoxychalcone, 10 g | sc-277693 | 10 g | $122.00 | |||
4,4′-Dimethoxychalcone, 25 g | sc-277693A | 25 g | $286.00 | |||
4,4′-Dimethoxychalcone, 50 g | sc-277693B | 50 g | $530.00 | |||
4,4′-Dimethoxychalcone, 100 g | sc-277693C | 100 g | $938.00 | |||
4,4′-Dimethoxychalcone, 250 g | sc-277693D | 250 g | $2040.00 |