Molecular structure of XRP44X, CAS Number: 729605-21-4
XRP44X (CAS 729605-21-4)
Application:
XRP44X is a Ras-Net (Elk-3) pathway inhibitor
CAS Number:
729605-21-4
Purity:
>99%
Molecular Weight:
380.88
Molecular Formula:
C21H21ClN4O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
XRP44X is a Ras-Net (Elk-3) pathway inhibitor (IC50 = 10-20 nM). Indirectly inhibits Net phosphorylation upstream of Erk1/2 activation. Mediates G2-M cell cycle arrest. Suppresses growth of multiple cell types (IC50 ~ 2 nM). XRP44X inhibits angiogenesis and acts as a microtubule depolymerizing agent by binding to the colchicine-binding site of Tubulin in vitro. XRP44X is an inhibitor of Tubulin.
XRP44X (CAS 729605-21-4) References
- Inhibition of the Ras-Net (Elk-3) pathway by a novel pyrazole that affects microtubules. | Wasylyk, C., et al. 2008. Cancer Res. 68: 1275-83. PMID: 18316589
- c-Jun N-terminal kinase mediates microtubule-depolymerizing agent-induced microtubule depolymerization and G2/M arrest in MCF-7 breast cancer cells. | Chen, J., et al. 2012. Anticancer Drugs. 23: 98-107. PMID: 21968419
- XRP44X, an Inhibitor of Ras/Erk Activation of the Transcription Factor Elk3, Inhibits Tumour Growth and Metastasis in Mice. | Semenchenko, K., et al. 2016. PLoS One. 11: e0159531. PMID: 27427904
- Elk-3 Contributes to the Progression of Liver Fibrosis by Regulating the Epithelial-Mesenchymal Transition. | Li, TZ., et al. 2017. Gut Liver. 11: 102-111. PMID: 27538444
- XRP44X Enhances the Cytotoxic Activity of Natural Killer Cells by Activating the c-JUN N-Terminal Kinase Signaling Pathway. | Kim, KS. and Park, KS. 2020. Dev Reprod. 24: 53-62. PMID: 32411918
- Design, synthesis and anticancer activity of 5-aryl-4-(4-arylpiperazine-1-carbonyl)-1,2,3-thiadiazoles as microtubule-destabilizing agents. | Wang, C., et al. 2021. Bioorg Chem. 106: 104199. PMID: 33317837
- Design, synthesis and biological evaluation of 1-Aryl-5-(4-arylpiperazine-1-carbonyl)-1H-tetrazols as novel microtubule destabilizers. | Wang, C., et al. 2021. J Enzyme Inhib Med Chem. 36: 549-560. PMID: 33522315
- A RAS inhibitor reduces allergic airway remodeling via regulating IL-33-derived type 2 innate lymphoid cells. | Tezuka, T., et al. 2021. Exp Lung Res. 47: 451-463. PMID: 34739349
- Research progress on antitumor activity of XRP44X and analogues as microtubule targeting agents. | Wang, C., et al. 2023. Front Chem. 11: 1096666. PMID: 36936533
- A novel microtubule inhibitor promotes tumor ferroptosis by attenuating SLC7A11/GPX4 signaling. | Ning, N., et al. 2023. Cell Death Discov. 9: 453. PMID: 38086802
Inhibitor of:
ATF-2, and Tubulin.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
XRP44X, 10 mg | sc-204404 | 10 mg | $175.00 | |||
XRP44X, 50 mg | sc-204404A | 50 mg | $739.00 |