v-SNARE Ykt6p Antibody (E-2): sc-365732
- v-SNARE Ykt6p Antibody (E-2) is a mouse monoclonal IgG2a κ v-SNARE Ykt6p antibody, cited in 15 publications, provided at 200 µg/ml
- raised against amino acids 1-198 representing full length v-SNARE Ykt6p of human origin
- v-SNARE Ykt6p Antibody (E-2) is recommended for detection of v-SNARE Ykt6p of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-v-SNARE Ykt6p Antibody (E-2) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for v-SNARE Ykt6p Antibody (E-2) for WB applications. These reagents are now offered in bundles with v-SNARE Ykt6p Antibody (E-2) (see ordering information below).
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v-SNARE Ykt6p Antibody (E-2) is a mouse monoclonal IgG2a kappa light chain antibody that detects v-SNARE Ykt6p of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-v-SNARE Ykt6p antibody (E-2) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. v-SNARE Ykt6p plays a crucial role in membrane trafficking within eukaryotic cells, facilitating the fusion of transport vesicles with their target membranes. This process is essential for the proper distribution of proteins and lipids throughout the cell, impacting various cellular functions such as secretion, nutrient uptake, and organelle maintenance. The interaction of v-SNAREs like v-SNARE Ykt6p with specific t-SNAREs ensures that vesicles reach their correct destinations, thereby maintaining cellular organization and function. Membrane interaction of v-SNARE Ykt6p is mediated by a unique cysteine/aliphatic/aliphatic/methionine or histidine (CAAX) C-terminal motif, which is critical for prenylation and subsequent membrane anchoring. v-SNARE Ykt6p interacts with t-SNARE Pep12p during Golgi prevacuolar transport and with cis-Golgi t-SNARE Sed5p, highlighting an integral role in the intricate network of intracellular trafficking.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
v-SNARE Ykt6p Antibody (E-2) References:
- Characterization of the sequence and expression of a Ykt6 prenylated SNARE from rat. | Catchpoole, DR. and Wanjin, H. 1999. DNA Cell Biol. 18: 141-5. PMID: 10073573
- Yeast Golgi SNARE interactions are promiscuous. | Tsui, MM. and Banfield, DK. 2000. J Cell Sci. 113 (Pt 1): 145-52. PMID: 10591633
- Asymmetric requirements for a Rab GTPase and SNARE proteins in fusion of COPII vesicles with acceptor membranes. | Cao, X. and Barlowe, C. 2000. J Cell Biol. 149: 55-66. PMID: 10747087
- An autoinhibitory mechanism for nonsyntaxin SNARE proteins revealed by the structure of Ykt6p. | Tochio, H., et al. 2001. Science. 293: 698-702. PMID: 11474112
- Ykt6p is a multifunctional yeast R-SNARE that is required for multiple membrane transport pathways to the vacuole. | Kweon, Y., et al. 2003. Mol Biol Cell. 14: 1868-81. PMID: 12802061
- Ykt6p, a prenylated SNARE essential for endoplasmic reticulum-Golgi transport. | McNew, JA., et al. 1997. J Biol Chem. 272: 17776-83. PMID: 9211930
- A human homolog can functionally replace the yeast vesicle-associated SNARE Vti1p in two vesicle transport pathways. | Fischer von Mollard, G. and Stevens, TH. 1998. J Biol Chem. 273: 2624-30. PMID: 9446565
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
v-SNARE Ykt6p Antibody (E-2) | sc-365732 | 200 µg/ml | $322.00 | |||
v-SNARE Ykt6p Antibody (E-2): m-IgG Fc BP-HRP Bundle | sc-529450 | 200 µg Ab; 10 µg BP | $361.00 | |||
v-SNARE Ykt6p Antibody (E-2): m-IgGκ BP-HRP Bundle | sc-522344 | 200 µg Ab, 40 µg BP | $361.00 | |||
v-SNARE Ykt6p Antibody (E-2) AC | sc-365732 AC | 500 µg/ml, 25% agarose | $424.00 | |||
v-SNARE Ykt6p Antibody (E-2) HRP | sc-365732 HRP | 200 µg/ml | $322.00 | |||
v-SNARE Ykt6p Antibody (E-2) FITC | sc-365732 FITC | 200 µg/ml | $336.00 | |||
v-SNARE Ykt6p Antibody (E-2) PE | sc-365732 PE | 200 µg/ml | $349.00 | |||
v-SNARE Ykt6p Antibody (E-2) Alexa Fluor® 488 | sc-365732 AF488 | 200 µg/ml | $364.00 | |||
v-SNARE Ykt6p Antibody (E-2) Alexa Fluor® 546 | sc-365732 AF546 | 200 µg/ml | $364.00 | |||
v-SNARE Ykt6p Antibody (E-2) Alexa Fluor® 594 | sc-365732 AF594 | 200 µg/ml | $364.00 | |||
v-SNARE Ykt6p Antibody (E-2) Alexa Fluor® 647 | sc-365732 AF647 | 200 µg/ml | $364.00 | |||
v-SNARE Ykt6p Antibody (E-2) Alexa Fluor® 680 | sc-365732 AF680 | 200 µg/ml | $364.00 | |||
v-SNARE Ykt6p Antibody (E-2) Alexa Fluor® 790 | sc-365732 AF790 | 200 µg/ml | $364.00 |