UDP-GlcDH Antibody (F-9): sc-166426
- UDP-GlcDH Antibody (F-9) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 37-64 near the N-terminus of UDP-GlcDH of human origin
- recommended for detection of UDP-glucose-6 dehydrogenase of mouse, rat, human and avian origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including and equine, canine, bovine, porcine and avian
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for UDP-GlcDH Antibody (F-9) for WB and IHC(P) applications. These reagents are now offered in bundles with UDP-GlcDH Antibody (F-9) (see ordering information below).
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UDP-GlcDH Antibody (F-9) is a mouse monoclonal IgG1 antibody that detects UDP-GlcDH in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). UDP-GlcDH, also known as UDP-glucose 6-dehydrogenase, plays a vital role in converting UDP-glucose to UDP-glucuronic acid, a key precursor in the biosynthesis of glycosaminoglycans such as hyaluronan, heparan sulfate, and chondroitin sulfate. These glycosaminoglycans are essential components of the extracellular matrix, contributing significantly to processes like signal transduction, cell migration, and cancer progression. UDP-GlcDH functions in the liver, where UDP-glucuronic acid is crucial for detoxification and excretion of harmful compounds. Structurally, UDP-GlcDH exists as a homohexamer, a configuration highly conserved across various species, demonstrating 97% sequence identity among different mammalian species. This conservation underscores UDP-GlcDH′s fundamental role in cellular metabolism and potential as a therapeutic target. Research has shown that TGFβ upregulates UDP-GlcDH expression, while hypoxia leads to downregulation, highlighting UDP-GlcDH′s involvement in cellular responses to environmental changes.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
UDP-GlcDH Antibody (F-9) | sc-166426 | 200 µg/ml | $322.00 | |||
UDP-GlcDH Antibody (F-9): m-IgG Fc BP-HRP Bundle | sc-540102 | 200 µg Ab; 10 µg BP | $361.00 | |||
UDP-GlcDH Antibody (F-9): m-IgG1 BP-HRP Bundle | sc-541905 | 200 µg Ab; 20 µg BP | $361.00 | |||
UDP-GlcDH (F-9) Neutralizing Peptide | sc-166426 P | 100 µg/0.5 ml | $69.00 |