TMPRSS2 Antibody (P5H9-A3): sc-101847
- TMPRSS2 Antibody (P5H9-A3) is a mouse monoclonal IgG1 κ, cited in 3 publications, provided at 200 µg/ml
- raised against a synthetic peptide corresponding to amino acids 350-365 of TMPRSS2 of human origin
- recommended for detection of TMPRSS2 of human origin by WB, IF and IHC(P)
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for TMPRSS2 Antibody (P5H9-A3). This work is in progress.
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TMPRSS2 Antibody (P5H9-A3) is a mouse monoclonal IgG1 antibody that detects TMPRSS2 in human samples through applications such as western blotting (WB), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). TMPRSS2 is a crucial serine protease encoded by the TMPRSS2 gene, consisting of 492 amino acids and primarily expressed in the prostate and kidney of mice, as well as in the human small intestine, prostate, colon, stomach, and salivary gland. TMPRSS2 features several important structural domains, including a serine protease domain from the S1 family, a scavenger receptor cysteine-rich domain, an LDL receptor class A domain, and a transmembrane domain, which collectively contribute to functional versatility. TMPRSS2 exists in both full-length form and a cleaved protease domain, with expression being upregulated by androgenic hormones. This regulation is particularly significant as TMPRSS2 has been implicated in prostate carcinogenesis, highlighting potential roles in tumor progression and metastasis. TMPRSS2′s ability to mediate the digestion of extracellular matrix components is essential for initial tumor growth and invasion, making anti-TMPRSS2 antibody (P5H9-A3) a valuable tool for research in cancer biology and therapeutic development.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TMPRSS2 Antibody (P5H9-A3) | sc-101847 | 200 µg/ml | $322.00 |