Thymosin β4 (CAS 77591-33-4)
QUICK LINKS
Thymosin β4 is an actin-sequestering peptide that modulates inflammation and healing in different tissues. It plays a major role in angiogenesis and tumor metastasis. Thymosin beta4 (Tβ4) is an extensively conserved protein known for its diverse biological functions. As a member of the thymosin protein family, Thymosin β4 plays a role in regulating the immune system, cell growth, and tissue healing. It is present in all vertebrates and is highly expressed in both embryonic and adult tissues. Tβ4 serves as a versatile protein that exhibits anti-inflammatory, antioxidant, and wound healing properties. It is actively involved in cell migration, tissue regeneration, and interacts with various proteins, such as growth factors, cytokines, and receptors. Through these interactions, Tβ4 modulates the activities of these proteins, influencing the cell′s response to different stimuli. Its effects encompass a wide range of biochemical and physiological processes, including the regulation of enzyme activity, gene expression, and signal transduction pathways. Additionally, Tβ4 impacts cell proliferation, migration, and differentiation, contributing to the overall complexity of its biological effects.
Thymosin β4 (CAS 77591-33-4) References
- Thymosin β4 expression in human tissues and in tumors using tissue microarrays. | Jo, JO., et al. 2011. Appl Immunohistochem Mol Morphol. 19: 160-7. PMID: 20975530
- Thymosin β4 as a restorative/regenerative therapy for neurological injury and neurodegenerative diseases. | Chopp, M. and Zhang, ZG. 2015. Expert Opin Biol Ther. 15 Suppl 1: S9-12. PMID: 25613458
- The role of thymosin-β4 in kidney disease. | Vasilopoulou, E., et al. 2015. Expert Opin Biol Ther. 15 Suppl 1: S187-90. PMID: 26096077
- Thymosin β4 Improves Differentiation and Vascularization of EHTs. | Ziegler, T., et al. 2017. Stem Cells Int. 2017: 6848271. PMID: 28191018
- Thymosin β4 in rheumatoid arthritis: Friend or foe. | Kim, KS. and Yang, HI. 2017. Biomed Rep. 7: 205-208. PMID: 28808568
- Thymosin β4 dynamics during chicken enteroid development. | Acharya, M., et al. 2021. Mol Cell Biochem. 476: 1303-1312. PMID: 33301106
- Thymosin β4 protects against aortic aneurysm via endocytic regulation of growth factor signaling. | Munshaw, S., et al. 2021. J Clin Invest. 131: PMID: 33784254
- Effects of thymosin β4-derived peptides on migration and invasion of ovarian cancer cells. | Yoon, HJ., et al. 2021. Genes Genomics. 43: 987-993. PMID: 34170491
- Thymosin β4 reverses phenotypic polarization of glial cells and cognitive impairment via negative regulation of NF-κB signaling axis in APP/PS1 mice. | Wang, M., et al. 2021. J Neuroinflammation. 18: 146. PMID: 34183019
- Thymosin β4 is essential for thrombus formation by controlling the G-actin/F-actin equilibrium in platelets. | Scheller, I., et al. 2022. Haematologica. 107: 2846-2858. PMID: 34348450
- Discovery of thymosin β4 as a human exerkine and growth factor. | Gonzalez-Franquesa, A., et al. 2021. Am J Physiol Cell Physiol. 321: C770-C778. PMID: 34495765
- Thymosin β4 Is an Endogenous Iron Chelator and Molecular Switcher of Ferroptosis. | Lachowicz, JI., et al. 2022. Int J Mol Sci. 23: PMID: 35008976
- Effects of Thymosin β4 on Myocardial Apoptosis in Burned Rats. | Wu, X., et al. 2022. J Healthc Eng. 2022: 2129629. PMID: 35281544
- Systemic gene therapy with thymosin β4 alleviates glomerular injury in mice. | Mason, WJ., et al. 2022. Sci Rep. 12: 12172. PMID: 35842494
- Thymosin β4 and the anti-fibrotic switch. | Kleinman, HK., et al. 2023. Int Immunopharmacol. 115: 109628. PMID: 36580759
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Thymosin β4, 1 mg | sc-396076 | 1 mg | $134.00 | |||
Thymosin β4, 100 mg | sc-396076A | 100 mg | $7140.00 |