NT-3 Antibody (J1407): sc-80250
- NT-3 Antibody (J1407) is a mouse monoclonal IgG1 κ NT-3 antibody, cited in 2 publications, provided at 100 µg/ml
- raised against a C-terminal region of NT-3 of human origin
- recommended for detection of NT-3 of human origin by ELISA
- also provided azide-free for neutralization, sc-80250 L, 100 µg/0.1 ml
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for NT-3 Antibody (J1407). This work is in progress.
NT-3 Antibody (J1407) is a mouse monoclonal IgG1 kappa light chain antibody that detects NT-3 protein of human origin by enzyme-linked immunosorbent assay (ELISA). Anti-NT-3 antibody (J1407) is available as a non-conjugated isotype antibody. Neurotrophin-3 (NT-3) plays a crucial role in the development and maintenance of the nervous system, particularly in the survival and differentiation of specific neuronal populations. NT-3 (J1407) monoclonal antibody is primarily located in the central nervous system and peripheral nervous system, where NT-3 binds to the Trk C receptor, promoting neuronal survival and growth. This interaction is vital for the proper functioning of sensory neurons and motor neurons, as NT-3 helps to ensure that these cells receive the necessary signals for their survival and development. The importance of NT-3 is underscored by involvement in various neurodegenerative diseases and injuries, where NT-3 expression can influence neuronal repair and regeneration. Anti-NT-3 antibody (J1407) enables valuable insights into the mechanisms of neurotrophic signaling and implications in neuronal health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
NT-3 Antibody (J1407) References:
- Reduction of NT-3 or TrkC results in fewer putative vagal mechanoreceptors in the mouse esophagus. | Raab, M., et al. 2003. Auton Neurosci. 108: 22-31. PMID: 14614961
- A role for NT-3 in the hyperinnervation of neonatally wounded skin. | Beggs, S., et al. 2012. Pain. 153: 2133-2139. PMID: 22871470
- NT-3 attenuates the growth of human neuron cells through the ERK pathway. | Li, R., et al. 2016. Cytotechnology. 68: 659-64. PMID: 25501303
- AAV-mediated NT-3 overexpression protects cochleae against noise-induced synaptopathy. | Chen, H., et al. 2018. Gene Ther. 25: 251-259. PMID: 29535374
- In schizophrenia serum level of neurotrophin-3 (NT-3) is increased only if depressive symptoms are present. | Arabska, J., et al. 2018. Neurosci Lett. 684: 152-155. PMID: 30098383
- The Biased Ligands NGF and NT-3 Differentially Stabilize Trk-A Dimers. | Ahmed, F., et al. 2021. Biophys J. 120: 55-63. PMID: 33285113
- Antidiabetic Effect of a New Original NT-3 Dipeptide Mimetic. | Yagubova, SS., et al. 2023. Dokl Biochem Biophys. 512: 241-244. PMID: 38093123
- Construction of functional neural network tissue combining CBD-NT3-modified linear-ordered collagen scaffold and TrkC-modified iPsc-derived neural stem cells for spinal cord injury repair. | Wu, Z., et al. 2024. Bioact Mater. 35: 242-258. PMID: 38333615
- NT-3 contributes to chemotherapy-induced neuropathic pain through TrkC-mediated CCL2 elevation in DRG neurons. | Sharma, D., et al. 2024. EMBO Rep. 25: 2375-2390. PMID: 38594391
- NT-3 and/or BDNF therapy prevents loss of auditory neurons following loss of hair cells. | Staecker, H., et al. 1996. Neuroreport. 7: 889-94. PMID: 8724667
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NT-3 Antibody (J1407) | sc-80250 | 100 µg/ml | $322.00 | |||
NT-3 Antibody (J1407) L | sc-80250 L | 100 µg/0.1 ml | $322.00 |