NOSIP Antibody (C-3): sc-137111

NOSIP Antibody (C-3) is a mouse monoclonal IgG2b antibody that detects NOSIP in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). NOSIP, or endothelial nitric oxide synthase interacting protein, plays a crucial role in modulating the activity of endothelial nitric oxide synthase (eNOS), an essential enzyme responsible for the production of nitric oxide (NO) in the vasculature. The regulation of eNOS is vital for maintaining vascular homeostasis, as nitric oxide is a key signaling molecule that influences vascular tone and blood flow. NOSIP achieves regulatory function by facilitating the translocation of eNOS from the plasma membrane to intracellular compartments, thereby inhibiting NO synthesis. This modulation is particularly important in various physiological processes, including the control of airway and vascular diameter, as well as the synthesis of NO in ciliated epithelial cells, which is critical for mucociliary clearance and bronchial function. Highly expressed in endothelial cells and vascularized tissues, NOSIP′s interaction with eNOS and other proteins such as caveolin-1 and Ca2+-calmodulin underscores significance in cardiovascular health and disease. Anti-NOSIP antibody (C-3) serves as an invaluable tool for researchers investigating the intricate mechanisms of nitric oxide signaling and implications in vascular biology.

The preferred NOSIP antibody is NOSIP Antibody (C-2): sc-365363.