Mindin Antibody (D-4): sc-376562

Mindin Antibody (D-4) is a mouse monoclonal IgG1 antibody that detects Mindin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Mindin, also known as Spondin-2 or DIL-1, plays a crucial role in cell adhesion and signaling, particularly in cancer, where Mindin expression can differ significantly between cancerous and non-cancerous cells. Mindin is primarily located on the cell surface and mediates interactions between cells and the extracellular matrix, which is vital for maintaining tissue integrity and facilitating cell communication. The structure of Mindin includes a hydrophobic signal sequence at the N-terminus, an FS1 domain, an FS2 domain, and a Thrombospondin type I repeat, which collectively contribute to Mindin′s ability to form dimers and oligomers, as demonstrated by immunoblot analysis under nonreducing conditions. These structural features are essential for Mindin′s function in promoting cell-to-cell and cell-to-matrix interactions, making anti-Mindin antibody (D-4) an invaluable tool for researchers studying cellular signaling and disease implications, particularly in cancer.

The preferred Mindin antibody is Mindin Antibody (A-10): sc-166868.