Δ17-Prostaglandin E1 (CAS 7046-45-9)
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Δ17-Prostaglandin E1 is a naturally occurring E-series prostaglandin produced by the COX metabolism of ω-3 arachidonic acid. It was first isolated and characterized as a product of ram seminal vesicle microsomes. The relative abundance of Δ17-PGE1 in humans and other animals is low in comparison with PGE2, and is likely to be a reflection of precursor fatty acid abundance in the phospholipid PUFA reservoir. Definitive studies on the biosynthesis of Δ17-PGE1 in intact animals have not been done. Δ17-PGE1 is about half as potent as PGE1 as an inhibitor of ADP-induced aggregation of rabbit PRP. In human PRP, Δ17-PGE1 is a more potent antiplatelet agonist than PGE1, with an IC50 of about 30 nM.3 The vascular effects of Δ17-PGE1 have not been reported.
Δ17-Prostaglandin E1 (CAS 7046-45-9) References
1 Samel, N., Järving, I., Lohmus, M., et al. Identification and biological activity of a novel natural prostaglandin, 5,6-dihydro-prostaglandin E3. Prostaglandins 33 137-146 (1987). 2 Kobzar, G., Mardla, V., Järving, I., et al. Comparison of the inhibitOrdering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Δ17-Prostaglandin E1, 1 mg | sc-205549 | 1 mg | $84.00 | |||
Δ17-Prostaglandin E1, 5 mg | sc-205549A | 5 mg | $379.00 |