CREB3L3 Antibody (F-9): sc-377331
- CREB3L3 Antibody (F-9) is a mouse monoclonal IgG1 κ, cited in 3 publications, provided at 200 µg/ml
- raised against amino acids 1-223 mapping at the N-terminus of CREB3L3 of mouse origin
- recommended for detection of CREB3L3 of mouse origin by WB, IP, IF and ELISA
- TransCruz reagent for ChIP application (sc-377331 X, 200 µg/0.1 ml)
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for CREB3L3 Antibody (F-9) for WB applications. These reagents are now offered in bundles with CREB3L3 Antibody (F-9) (see ordering information below).
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CREB3L3 Antibody (F-9) is a mouse monoclonal IgG1 antibody that detects CREB3L3 in mouse samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CREB3L3, also known as cAMP-responsive element-binding protein 3-like protein 3 or HYST1481, is a 461 amino acid single-pass type II membrane protein primarily localized to the endoplasmic reticulum (ER). CREB3L3 undergoes cleavage during ER stress and translocates to the nucleus to function as a transcription factor. This translocation activates genes involved in the unfolded protein response and the acute phase response, both vital for cellular homeostasis and stress management. CREB3L3 is underexpressed in hepatocellular carcinoma, indicating potential tumor suppressor function. CREB3L3 operates as a dimer and features a leucine zipper domain, a KDEL-like sequence, and a bZIP domain, which are essential for DNA binding capabilities. Alternative splicing results in three isoforms of CREB3L3, further diversifying functional roles in cellular processes.
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CREB3L3 Antibody (F-9) References:
- Intestinal CREBH overexpression prevents high-cholesterol diet-induced hypercholesterolemia by reducing Npc1l1 expression. | Kikuchi, T., et al. 2016. Mol Metab. 5: 1092-1102. PMID: 27818935
- CREBH Maintains Circadian Glucose Homeostasis by Regulating Hepatic Glycogenolysis and Gluconeogenesis. | Kim, H., et al. 2017. Mol Cell Biol. 37: PMID: 28461393
- CREBH Regulates Systemic Glucose and Lipid Metabolism. | Nakagawa, Y. and Shimano, H. 2018. Int J Mol Sci. 19: PMID: 29738435
- Starvation-induced transcription factor CREBH negatively governs body growth by controlling GH signaling. | Nakagawa, Y., et al. 2021. FASEB J. 35: e21663. PMID: 34042217
- CREBH normalizes dyslipidemia and halts atherosclerosis in diabetes by decreasing circulating remnant lipoproteins. | Shimizu-Albergine, M., et al. 2021. J Clin Invest. 131: PMID: 34491909
- CREBH Systemically Regulates Lipid Metabolism by Modulating and Integrating Cellular Functions. | Nakagawa, Y., et al. 2021. Nutrients. 13: PMID: 34579081
- A hepatokine derived from the ER protein CREBH promotes triglyceride metabolism by stimulating lipoprotein lipase activity. | Kim, H., et al. 2023. Sci Signal. 16: eadd6702. PMID: 36649378
- CREBH promotes autophagy to ameliorate NASH by regulating Coro1a. | Deng, X., et al. 2024. Biochim Biophys Acta Mol Basis Dis. 1870: 166914. PMID: 37837948
- Dietary medium-chain fatty acids reduce hepatic fat accumulation via activation of a CREBH-FGF21 axis. | Cao, Y., et al. 2024. Mol Metab. 87: 101991. PMID: 39019116
- ER-tethered stress sensor CREBH regulates mitochondrial unfolded protein response to maintain energy homeostasis. | Kim, H., et al. 2024. Proc Natl Acad Sci U S A. 121: e2410486121. PMID: 39589874
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CREB3L3 Antibody (F-9) | sc-377331 | 200 µg/ml | $322.00 | |||
CREB3L3 Antibody (F-9): m-IgG Fc BP-HRP Bundle | sc-551149 | 200 µg Ab; 10 µg BP | $361.00 | |||
CREB3L3 Antibody (F-9): m-IgGκ BP-HRP Bundle | sc-551145 | 200 µg Ab; 40 µg BP | $361.00 | |||
CREB3L3 Antibody (F-9) X | sc-377331 X | 200 µg/0.1 ml | $322.00 |