ADH4 Antikörper (NB-B2): sc-134249

ADH4 (alcohol dehydrogenase 4) is a 380 amino acid protein that belongs to the zinc-containing alcohol dehydrogenase family of enzymes that function to metabolize a wide variety of substrates, including retinol, hydroxysteroids, ethanol, aliphatic alcohols and lipid peroxidation products. Localized to the cytoplasm and existing as a homodimer, ADH4 uses zinc as a cofactor to catalyze the NAD+-dependent conversion of an alcohol to an aldehyde or a ketone, thereby participating in the metabolic degradation of alcohols within the body. Multiple isoforms of ADH4 exist due to alternative splicing events. The gene encoding ADH4 maps to a cluster of alcohol dehydrogenase genes on human chromosome 4, a chromosome that encodes nearly 6% of the human genome and has the largest gene deserts (regions of the genome with no protein encoding genes) of all of the human chromosomes.