7-Hydroxyaristolochic acid A CAS: 79185-75-4
MF: C17H11NO8
MW: 357.27
An aristolochic acid associated with urothelial carcinoma formation.

7-Hydroxyaristolochic acid A (CAS 79185-75-4)

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Alternative Namen: 6-nitronaphtho[2,1-g][1,3]benzodioxole-5-carboxylic acid
Anwendungen 7-Hydroxyaristolochic acid A is an aristolochic acid associated with urothelial carcinoma formation
CAS Nummer: 79185-75-4
Molekulargewicht: 357.27
Summenformel: C17H11NO8
Ausschließlich für Forschungszwecke. Nicht Geeignet für Verwendung in Diagnostik oder Therapie.
* Schauen Sie auf das Analysezertifikat (CoA), um die genauen Daten (inkl. Wassergehalt) Ihrer Produktionscharge (Lot) zu sehen.

7-Hydroxyaristolochic acid A is an aristolochic acid. These compounds are the active ingredients, responsible for the hepatoxicity and renal toxicity, found in Aristolochic fangchi. They form DNA adducts in renal tissue and are associated with urothelial carcinoma formation.


Literaturhinweise

1. Pfau, W., et al., 1990. 32P-postlabelling analysis of the DNA adducts formed by aristolochic acid I and II. Carcinogenesis. 11(9): 1627-33. PMID: 2401053
2. Rossiello, M R., et al., 1993. Induction of hepatic nodules in the rat by aristolochic acid. Cancer letters. 71(1-3): 83-7. PMID: 8364902
3. Mengs, U., et al., 1993. Renal toxicity of aristolochic acid in rats as an example of nephrotoxicity testing in routine toxicology. Archives of toxicology. 67(5): 307-11. PMID: 8368940
4. Hadjiolov, D., et al., 1993. Effect of diallyl sulfide on aristolochic acid-induced forestomach carcinogenesis in rats. Carcinogenesis. 14(3): 407-10. PMID: 8453716
5. Schmeiser, H H., et al., 1996. Detection of DNA adducts formed by aristolochic acid in renal tissue from patients with Chinese herbs nephropathy. Cancer research. 56(9): 2025-8. PMID: 8616845
6. Levi, M., et al., 1998. Acute hepatitis in a patient using a Chinese herbal tea--a case report. Pharmacy world & science : PWS. 20(1): 43-4. PMID: 9536471
7. Nortier, J L., et al., 2000. Urothelial carcinoma associated with the use of a Chinese herb (Aristolochia fangchi) The New England journal of medicine. 342(23): 1686-92. PMID: 10841870

Aggregatzustand :
Solid
Löslichkeit :
Soluble in water.
LAGERUNG: :
Store at -20° C
Schmelztemperatur :
287-292° C
Ausschließlich für Forschungszwecke. Nicht Geeignet für Verwendung in Diagnostik oder Therapie.
PubChem CID :
SMILES :
COC1=C(C=CC2=C3C(=C(C=C21)[N+](=O)[O-])C(=CC4=C3OCO4)C(=O)O)O

SDS (MSDS) herunterladen

Analysenzertifikat

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