Cholesteryl hemisuccinate (CAS 1510-21-0)
Alternate Names:
3β-Hydroxy-5-cholestene 3-hemisuccinate; 5-Cholesten-3β-ol 3-hemisuccinate; Cholesteryl hydrogen succinate
CAS Number:
1510-21-0
Molecular Weight:
486.74
Molecular Formula:
C31H50O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Cholesteryl hemisuccinate (CHS) is a synthetic compound formed by combining cholesterol with succinic acid. It serves as useful in laboratory experiments aimed at investigating the influence of cholesterol. In the realm of scientific research, Cholesteryl hemisuccinateproves versatile and applicable to a range of investigations. Particularly, it is frequently employed in the study of cell membranes due to its capacity to interact with and modify membrane properties. Understanding the mechanism of action of Cholesteryl hemisuccinateis a complex endeavor, primarily rooted in its interactions with cell membranes. By interacting with the membrane, Cholesteryl hemisuccinate can induce alterations in permeability and fluidity, subsequently impacting the activity of embedded proteins, enzymes, and hormones.
Cholesteryl hemisuccinate (CAS 1510-21-0) References
- Cholesteryl hemisuccinate exhibits pH sensitive polymorphic phase behavior. | Hafez, IM. and Cullis, PR. 2000. Biochim Biophys Acta. 1463: 107-14. PMID: 10631299
- Cholesteryl-hemisuccinate-induced apoptosis of promyelocytic leukemia HL-60 cells through a cyclosporin A-insensitive mechanism. | Yamada, K., et al. 2003. Biochem Pharmacol. 65: 339-48. PMID: 12527327
- Cholesteryl hemisuccinate as a membrane stabilizer in dipalmitoylphosphatidylcholine liposomes containing saikosaponin-d. | Ding, WX., et al. 2005. Int J Pharm. 300: 38-47. PMID: 15978754
- Relationship between Thylakoid Membrane Fluidity and the Functioning of Pea Chloroplasts : EFFECT OF CHOLESTERYL HEMISUCCINATE. | Yamamoto, Y., et al. 1981. Plant Physiol. 67: 1069-72. PMID: 16661811
- Preparation and characterization of pH-sensitive vesicles made of cholesteryl hemisuccinate. | Xu, H., et al. 2008. Drug Dev Ind Pharm. 34: 134-41. PMID: 18302031
- How well does cholesteryl hemisuccinate mimic cholesterol in saturated phospholipid bilayers? | Kulig, W., et al. 2014. J Mol Model. 20: 2121. PMID: 24526383
- Experimental determination and computational interpretation of biophysical properties of lipid bilayers enriched by cholesteryl hemisuccinate. | Kulig, W., et al. 2015. Biochim Biophys Acta. 1848: 422-32. PMID: 25450348
- Cholesteryl hemiesters alter lysosome structure and function and induce proinflammatory cytokine production in macrophages. | Domingues, N., et al. 2017. Biochim Biophys Acta Mol Cell Biol Lipids. 1862: 210-220. PMID: 27793708
- Capacity of cholesteryl hemisuccinate in ion pair/phospholipid complex to improve drug-loading, stability and antibacterial activity of clarithromycin intravenous lipid microsphere. | Luo, L., et al. 2018. Colloids Surf B Biointerfaces. 172: 262-271. PMID: 30173093
- Cholesteryl Hemisuccinate Is Not a Good Replacement for Cholesterol in Lipid Nanodiscs. | Augustyn, B., et al. 2019. J Phys Chem B. 123: 9839-9845. PMID: 31674185
- Distinctive Weak Interactions Underlie Diverse Nucleation and Small-Angle Scattering Behavior of Aqueous Cholesterol, Cholesteryl Hemisuccinate, and Glycocholic Acid. | Hazra, R. and Roy, D. 2021. J Phys Chem B. 125: 612-624. PMID: 33417461
- pH-Responsive Liposomes of Dioleoyl Phosphatidylethanolamine and Cholesteryl Hemisuccinate for the Enhanced Anticancer Efficacy of Cisplatin. | Shah, H., et al. 2022. Pharmaceutics. 14: PMID: 35057025
- Cholesteryl hemisuccinate alters membrane fluidity, angiotensin receptors, and responses in adrenal glomerulosa cells. | Carroll, JE., et al. 1983. Life Sci. 32: 1573-81. PMID: 6300585
- Cholesteryl hemisuccinate treatment protects rodents from the toxic effects of acetaminophen, adriamycin, carbon tetrachloride, chloroform and galactosamine. | Fariss, MW., et al. 1997. Toxicol Lett. 90: 133-44. PMID: 9067481
- Effect of cholesteryl hemisuccinate on the interfacial properties of phosphatidylcholine bilayers. | Massey, JB. 1998. Biochim Biophys Acta. 1415: 193-204. PMID: 9858729
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ABCG1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Cholesteryl hemisuccinate, 5 g | sc-486449 | 5 g | $306.00 |