Molecular structure of 6,7-Dihydroxy-4-methylcoumarin, CAS Number: 529-84-0
6,7-Dihydroxy-4-methylcoumarin (CAS 529-84-0)
Alternate Names:
4-Methylesculetin
Application:
6,7-Dihydroxy-4-methylcoumarin is a product suitable as a pH-indicator
CAS Number:
529-84-0
Purity:
≥97%
Molecular Weight:
192.17
Molecular Formula:
C10H8O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
6,7-dihydroxy-4-methylcoumarin is a compound belonging to the hydroxycoumarin family, specifically a derivative of 4-methylcoumarin with hydroxy groups present at positions 3 and 4. It functions as a potent inhibitor of hyaluronan synthesis. Additionally, it has demonstrated utility as a fluorescent sensor for tracking the consumption of a boronic acid during Suzuki coupling reactions. The fluorescence emitted by this compound can be easily observed using a standard 365 nm UV lamp. 6,7-Dihydroxy-4-methylcoumarin is suitable as a pH-indicator.
6,7-Dihydroxy-4-methylcoumarin (CAS 529-84-0) References
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- Structural requirements of hydroxylated coumarins for in vitro anti-Helicobacter pylori activity. | Kawase, M., et al. 2003. In Vivo. 17: 509-12. PMID: 14598616
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- Structure-activity relationship of dihydroxy-4-methylcoumarins as powerful antioxidants: correlation between experimental & theoretical data and synergistic effect. | Kancheva, VD., et al. 2010. Biochimie. 92: 1089-100. PMID: 20600568
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- Short- and long-term regulation of 3-hydroxy 3-methylglutaryl coenzyme A reductase by a 4-methylcoumarin. | Trapani, L., et al. 2011. Biochimie. 93: 1165-71. PMID: 21530605
- Evaluation of the antioxidant activity of several naturally occurring coumarins and their synthesized analogues by 'ferric reducing antioxidant power' assay. | Rehakova, Z., et al. 2014. J Enzyme Inhib Med Chem. 29: 49-54. PMID: 23356333
- UDP-Glucuronosyltransferases 1A6 and 1A9 are the Major Isozymes Responsible for the 7-O-Glucuronidation of Esculetin and 4-Methylesculetin in Human Liver Microsomes. | Zhu, L., et al. 2015. Drug Metab Dispos. 43: 977-83. PMID: 25854527
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- Mannich bases of hydroxycoumarins: synthesis, DFT/QTAIM computational study and assessment of biological activity. | Durand-Niconoff, JS., et al. 2021. RSC Adv. 11: 31260-31271. PMID: 35496885
- Pharmacological and biochemical actions of simple coumarins: natural products with therapeutic potential. | Hoult, JR. and Payá, M. 1996. Gen Pharmacol. 27: 713-22. PMID: 8853310
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
6,7-Dihydroxy-4-methylcoumarin, 25 g | sc-291439 | 25 g | $175.00 |