Hypoxanthine (CAS 68-94-0)
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Hypoxanthine can be used as a marker for energy perturbation in hypoxia/ischemia and is structurally related to 6-mercaptopurine. The compound has been used in studies as in indicator, along with uric acid (sc-213135) and allantoin (sc-207271), of in vivo free radical reactions. To understand its biological implications, hypoxanthine has been used in DNA studies to investigate the destabilizing effect it has on DNA duplexes containing hypoxanthine as a base, in a gas phase versus a liquid phase. Hypoxanthine has also been used in studies along with 8-oxoguanine nucleotides to investigate their interaction with human DNA pol α (DNA polymerase alpha) and DNA polymerase I from Bacillus stearothermophilus. Hypoxanthine, a purine nucleoside, serves as a intermediate in the metabolism of purine nucleotides. This naturally occurring compound is present in various organisms and acts as a precursor to the purine nucleotides adenine and guanine. Hypoxanthine assumes a significant role within the purine nucleotide cycle, contributing to energy metabolism as well as the synthesis of DNA and RNA.
Hypoxanthine (CAS 68-94-0) References
- Hypoxanthine, uric acid and allantoin as indicators of in vivo free radical reactions. Description of a HPLC method and human brain microdialysis data. | Marklund, N., et al. 2000. Acta Neurochir (Wien). 142: 1135-41; discussion 1141-2. PMID: 11129536
- Interaction of human DNA polymerase alpha and DNA polymerase I from Bacillus stearothermophilus with hypoxanthine and 8-oxoguanine nucleotides. | Patro, JN., et al. 2009. Biochemistry. 48: 8271-8. PMID: 19642651
- 13C chemical shift tensors in hypoxanthine and 6-mercaptopurine: effects of substitution, tautomerism, and intermolecular interactions. | Malináková, K., et al. 2010. J Phys Chem A. 114: 1985-95. PMID: 20055404
- Stability of DNA duplexes containing hypoxanthine (inosine): gas versus solution phase and biological implications. | Sun, X. and Lee, JK. 2010. J Org Chem. 75: 1848-54. PMID: 20184296
- Progress and recent advances in fabrication and utilization of hypoxanthine biosensors for meat and fish quality assessment: a review. | Lawal, AT. and Adeloju, SB. 2012. Talanta. 100: 217-28. PMID: 23141330
- Hypoxanthine causes endothelial dysfunction through oxidative stress-induced apoptosis. | Kim, YJ., et al. 2017. Biochem Biophys Res Commun. 482: 821-827. PMID: 27888108
- Hypoxanthine transport and metabolism in the central nervous system. | Spector, R. 1988. J Neurochem. 50: 969-78. PMID: 3123609
- Proof of concept: hypoxanthine from stored red blood cells induces neutrophil activation. | Marraccini, C., et al. 2022. Blood Transfus. 20: 120-126. PMID: 33370225
- Hypoxanthine and lactate concentrations in lambs during hypoxic and stagnant hypoxia. | Moss, M., et al. 1988. Am J Physiol. 255: H53-9. PMID: 3394825
- Toxicological effects of hypoxanthine on Heterosigmaakashiwo: Mechanism of growth inhibition and change in hemolytic toxin content. | Chen, B., et al. 2021. Ecotoxicol Environ Saf. 226: 112797. PMID: 34571425
- Orange emissive carbon dots for fluorescent determination of hypoxanthine in fish. | Mou, Z., et al. 2022. Spectrochim Acta A Mol Biomol Spectrosc. 269: 120734. PMID: 34922290
- Review on recent advances in fabrication of enzymatic and chemical sensors for hypoxanthine. | Garg, D., et al. 2022. Food Chem. 375: 131839. PMID: 34968951
- Hypoxanthine Reduces Radiation Damage in Vascular Endothelial Cells and Mouse Skin by Enhancing ATP Production via the Salvage Pathway. | Fujiwara, M., et al. 2022. Radiat Res. 197: 583-593. PMID: 35334490
- Plasma hypoxanthine and exercise. | Ketai, LH., et al. 1987. Am Rev Respir Dis. 136: 98-101. PMID: 3605851
- Hypoxanthine transport through the blood-brain barrier. | Spector, R. 1987. Neurochem Res. 12: 791-6. PMID: 3670521
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Hypoxanthine, 25 g | sc-29068 | 25 g | $68.00 |