Date published: 2025-11-17

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D-Valine (CAS 640-68-6)

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Alternate Names:
(R)-α-Aminoisovaleric acid; D-2-Amino-3-methylbutanoic acid
Application:
D-Valine is an isomer of the essential amino acid L-Valine
CAS Number:
640-68-6
Molecular Weight:
117.15
Molecular Formula:
C5H11NO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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D-Valine is a selective inhibitor of cell proliferation. It inhibit cells that lack the enzyme D-amino acid oxidase. D-Valine may act to inhibit fibroblast growth while allowing selective growth of epithelial cells.


D-Valine (CAS 640-68-6) References

  1. Growth of transplastomic cells expressing D-amino acid oxidase in chloroplasts is tolerant to D-alanine and inhibited by D-valine.  |  Gisby, MF., et al. 2012. Plant Physiol. 160: 2219-26. PMID: 23085840
  2. D-valine as a selective agent for normal human and rodent epithelial cells in culture.  |  Gilbert, SF. and Migeon, BR. 1975. Cell. 5: 11-7. PMID: 236834
  3. Isolation and characterization of L-valine-degrading Candida maltosa DLPU-zpb for D-valine preparation from DL-valine.  |  Zhang, CH., et al. 2015. Lett Appl Microbiol. 61: 453-9. PMID: 26250528
  4. Application and microbial preparation of D-valine.  |  Chen, M., et al. 2016. World J Microbiol Biotechnol. 32: 171. PMID: 27565781
  5. Effects of d-valine on periodontal or peri-implant pathogens: Porphyromonas gingivalis biofilm.  |  Qi, H., et al. 2018. J Periodontol. 89: 303-314. PMID: 29520781
  6. Equilibrium and Kinetic Study of l- and d-Valine Adsorption in Supramolecular-Templated Chiral Mesoporous Materials.  |  Huang, Y. and Garcia-Bennett, AE. 2021. Molecules. 26: PMID: 33440748
  7. Culture of bovine mammary epithelial cells in D-valine modified medium: selective removal of contaminating fibroblasts.  |  Sordillo, LM., et al. 1988. Cell Biol Int Rep. 12: 355-64. PMID: 3401935
  8. Gramicidin A is hydrolyzed by a d-stereospecific peptidase produced by Bacillus anthracis.  |  Kaman, WE., et al. 2022. Environ Microbiol Rep. 14: 570-576. PMID: 35403341
  9. Functionalization of Keggin Fe13-Oxo Clusters.  |  Chen, MT., et al. 2023. Inorg Chem. 62: 1781-1785. PMID: 35608919
  10. A novel process using immobilized engineered strain HC01 cells with co-expressed D-hydantoinase and D-N-carbamoylase as biocatalyst for the production of D-Valine.  |  Niu, L., et al. 2023. Bioprocess Biosyst Eng. 46: 227-236. PMID: 36478291
  11. Mutual antagonism in the metabolism of D-valine and D-leucine and antagonism by their analogs.  |  Cruz, LJ., et al. 1969. Arch Biochem Biophys. 135: 341-9. PMID: 4391341
  12. Oxidation of D- and L-valine by enzymes of Pseudomonas aeruginosa.  |  Norton, JE. and Sokath, JR. 1966. J Bacteriol. 92: 116-20. PMID: 4957429
  13. Effects of D-valine on pulmonary artery endothelial cell morphology and function in cell culture.  |  Picciano, PT., et al. 1984. Exp Cell Res. 151: 134-47. PMID: 6421609
  14. D-valine medium maintains prolactin production in primary culture.  |  Padmanabhan, V., et al. 1982. Mol Cell Endocrinol. 28: 613-26. PMID: 6818057
  15. Epimerization of the D-valine portion in the biosynthesis of actinomycin D.  |  Stindl, A. and Keller, U. 1994. Biochemistry. 33: 9358-64. PMID: 8049237

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

D-Valine, 5 g

sc-257298
5 g
$32.00

D-Valine, 25 g

sc-257298B
25 g
$51.00

D-Valine, 100 g

sc-257298A
100 g
$77.00

D-Valine, 250 g

sc-257298C
250 g
$102.00

D-Valine, 1 kg

sc-257298D
1 kg
$367.00

D-Valine, 5 kg

sc-257298E
5 kg
$1734.00