Date published: 2025-12-5

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2(5H)-Furanone (CAS 497-23-4)

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Alternate Names:
γ-Crotonolactone; 2-Buten-1,4-olide
CAS Number:
497-23-4
Molecular Weight:
84.07
Molecular Formula:
C4H4O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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2(5H)-Furanone is a heterocyclic organic compound. This colorless liquid possesses solubility in most organic solvents. 2(5H)-Furanone demonstrates numerous scientific research applications, particularly in the synthesis of natural products such as terpenes, steroids, and alkaloids. Additionally, 2(5H)-Furanone serves as a ligand in coordination chemistry and functions as a reagent in organic synthesis. As an electrophile, 2(5H)-Furanone possesses the ability to react with nucleophiles, leading to the formation of covalent bonds. This reaction involves the creation of a carbon-oxygen bond, which gains stability through resonance. It is recognized as a nucleophilic addition reaction.


2(5H)-Furanone (CAS 497-23-4) References

  1. Alpha-pyrones and a 2(5H)-furanone from Hyptis pectinata.  |  Boalino, DM., et al. 2003. Phytochemistry. 64: 1303-7. PMID: 14599529
  2. [2 + 2] Photocycloaddition of 2(5H)-furanone to unsaturated compounds. insights from first principles calculations and transient-absorption measurements.  |  Cucarull-González, JR., et al. 2010. J Org Chem. 75: 4392-401. PMID: 20518511
  3. 2(5H)-Furanone: A Prospective strategy for biofouling-control in membrane biofilm bacteria by quorum sensing inhibition.  |  Ponnusamy, K., et al. 2010. Braz J Microbiol. 41: 227-34. PMID: 24031485
  4. 2(5H)-Furanone, epigallocatechin gallate, and a citric-based disinfectant disturb quorum-sensing activity and reduce motility and biofilm formation of Campylobacter jejuni.  |  Castillo, S., et al. 2015. Folia Microbiol (Praha). 60: 89-95. PMID: 25231135
  5. Unraveling the Molecular Mechanism of Selective Antimicrobial Activity of 2(5H)-Furanone Derivative against Staphylococcus aureus.  |  Sharafutdinov, IS., et al. 2019. Int J Mol Sci. 20: PMID: 30736278
  6. A Divergent Paired Electrochemical Process for the Conversion of Furfural Using a Divided-Cell Flow Microreactor.  |  Cao, Y., et al. 2021. ChemSusChem. 14: 590-594. PMID: 33305485
  7. Characterization of Key Odorants in Scallion Pancake and Investigation on Their Changes during Storage.  |  Liu, B., et al. 2021. Molecules. 26: PMID: 34946729
  8. Anticancer and Apoptotic Activity in Cervical Adenocarcinoma HeLa Using Crude Extract of Ganoderma applanatum.  |  Kiddane, AT., et al. 2022. Curr Issues Mol Biol. 44: 1012-1026. PMID: 35723290
  9. A Brominated Furanone Inhibits Pseudomonas aeruginosa Quorum Sensing and Type III Secretion, Attenuating Its Virulence in a Murine Cutaneous Abscess Model.  |  Muñoz-Cázares, N., et al. 2022. Biomedicines. 10: PMID: 36009394
  10. Novel Insight into the Volatile Profile and Antioxidant Properties of Crocus sativus L. Flowers.  |  Cerdá-Bernad, D., et al. 2022. Antioxidants (Basel). 11: PMID: 36139726
  11. Bringing Antimicrobial Strategies to a New Level: The Quorum Sensing System as a Target to Control Streptococcus suis.  |  Xue, B., et al. 2022. Life (Basel). 12: PMID: 36556371
  12. Chemical Composition Profiling and Antifungal Activity of Saffron Petal Extract.  |  Naim, N., et al. 2022. Molecules. 27: PMID: 36557875
  13. Investigation of aroma characteristics of seven Chinese commercial sunflower seed oils using a combination of descriptive Analysis, GC-quadrupole-MS, and GC-Orbitrap-MS.  |  Liu, J., et al. 2023. Food Chem X. 18: 100690. PMID: 37179977
  14. Variation in mouse chemical signals is genetically controlled and environmentally modulated.  |  Stopková, R., et al. 2023. Sci Rep. 13: 8573. PMID: 37237091

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

2(5H)-Furanone, 1 g

sc-251889
1 g
$54.00

2(5H)-Furanone, 5 g

sc-251889A
5 g
$262.00