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5-Chlorosalicylic acid (CAS 321-14-2)

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Alternate Names:
5-Chloro-2-hydroxybenzoic acid
CAS Number:
321-14-2
Molecular Weight:
172.57
Molecular Formula:
C7H5ClO3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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5-Chlorosalicylic acid, also referred to as 5-chloro-2-hydroxybenzoic acid, is a synthetic compound widely utilized within the scientific community for various purposes. As an aromatic acid, it contains a benzene ring in its structure and falls under the category of phenolic acids. The compound appears as a white crystalline powder that readily dissolves in water and possesses a melting point of around 195°C. Its versatility has made it an indispensable component in numerous laboratory experiments and scientific research endeavors. This compound has found extensive application in diverse scientific research studies. Moreover, it has proven valuable in the synthesis of other compounds, including 5-Chlorosalicylic acidydroxybenzamide and 5-Chlorosalicylic acidydroxybenzoic anhydride. The mechanism of action of 5-Chlorosalicylic acid involves inhibiting the activity of enzymes known as cyclooxygenases (COX). 5-Chlorosalicylic acid holds an indispensable position in the scientific realm due to its multifaceted applications and its role in understanding cellular processes.


5-Chlorosalicylic acid (CAS 321-14-2) References

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  2. Absorption, distribution, and metabolic fate of 7-chloro-3,3a-dihydro-2-methyl-2H,9H-isoxazolo-(3,2-b)(1,3)-benzoxazin-9-one in rats, dogs, and humans.  |  Edelson, J., et al. 1975. J Pharm Sci. 64: 1316-21. PMID: 1097636
  3. Comparative anti-inflammatory, analgesic, and antipyretic activities of 7-chloro-3,3a-dihydro-2-methyl-2H,9H-isoxazolo-(3,2-b)(1,3)-benzoxazin-9-one and 5-chlorosalicylic acid in rats.  |  Sofia, RD., et al. 1975. J Pharm Sci. 64: 1321-4. PMID: 1151704
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  6. Deciphering the photophysics of 5-chlorosalicylic acid: evidence for excited-state intramolecular proton transfer.  |  Paul, BK., et al. 2010. Photochem Photobiol Sci. 9: 57-67. PMID: 20062845
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  8. Ligand-Controlled Regiodivergent Thiocarbonylation of Alkynes toward Linear and Branched α,β-Unsaturated Thioesters.  |  Ai, HJ., et al. 2021. Angew Chem Int Ed Engl. 60: 17178-17184. PMID: 34058046
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  14. Comparative antiphlogistic activity of meseclazone, 5-chlorosalicylic acid, acetylsalicylic acid, phenylbutazone, indomethacin and hydrocortisone in various rat paw edema models.  |  Sofia, RD. 1978. Pharmacology. 16: 148-52. PMID: 628674
  15. Comparative gastric ulcerogenic effects of meseclazone, 5-chlorosalicylic acid and other nonsteroidal anti-inflammatory drugs following acute and repeated oral administration to rats.  |  Diamantis, W., et al. 1980. Toxicol Appl Pharmacol. 52: 454-61. PMID: 6768168

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

5-Chlorosalicylic acid, 100 g

sc-239038
100 g
$22.00