3,4,5-Trimethoxybenzoyl chloride (CAS 4521-61-3)

3,4,5-Trimethoxybenzoyl chloride (TMBCl) is a white, organic compound with the chemical formula C10H11O4Cl. This substance readily dissolves in organic solvents like ethanol and acetone. It plays a vital role in various organic synthesis processes, facilitating the creation of amides, esters, and aromatic compounds. Moreover, 3,4,5-Trimethoxybenzoyl chloride functions as a catalyst in several reactions, including the Wittig, Stille, and Heck reactions.In the realm of scientific research, 3,4,5-Trimethoxybenzoyl chloride is a used reagent for the synthesis of amides, esters, and aromatic compounds. Its applications extend to agrochemical synthesis.It finds utility in polymerization processes, such as the production of polyesters and polyurethanes, as well as the synthesis of polyamides and polyimides.In catalytic reactions, 3,4,5-Trimethoxybenzoyl chloride showcases its versatility. In the Wittig reaction, it acts as a Lewis acid, forming a π-complex with an alkene, which is then attacked by a phosphonium ylide to yield an alkene product. In the Stille reaction, this compound serves as a nucleophile, participating in the formation of new carbon-carbon bonds by attacking palladium-carbon bonds. Lastly, in the Heck reaction, 3,4,5-Trimethoxybenzoyl chloride functions as an electrophile, reacting with alkynes to produce alkenes.