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2,6-Dimethylaniline (CAS 87-62-7)

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Alternate Names:
2,6-Xylidine
CAS Number:
87-62-7
Purity:
≥95%
Molecular Weight:
121.18
Molecular Formula:
(CH3)2C6H3NH2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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2,6-Dimethylaniline is a chemical compound that functions as a reagent in various organic synthesis reactions. It acts as a nucleophilic aromatic substitution reagent, participating in reactions to introduce alkyl or acyl groups onto aromatic rings. 2,6-Dimethylaniline′s mechanism of action involves its ability to donate a lone pair of electrons to an electrophilic aromatic system, leading to the formation of new carbon-carbon bonds. In experimental applications, 2,6-Dimethylaniline is utilized as a building block for the synthesis of agrochemicals, and dyes. Its molecular structure allows it to participate in a range of synthetic transformations, making it useful for the construction of complex organic molecules. 2,6-Dimethylaniline′s role in its capacity to facilitate the creation of novel chemical entities through its involvement in diverse synthetic pathways.


2,6-Dimethylaniline (CAS 87-62-7) References

  1. Oxidation of 2,6-dimethylaniline by recombinant human cytochrome P450s and human liver microsomes.  |  Gan, J., et al. 2001. Chem Res Toxicol. 14: 672-7. PMID: 11409937
  2. Analysis of the lidocaine metabolite 2,6-dimethylaniline in bovine and human milk.  |  Puente, NW. and Josephy, PD. 2001. J Anal Toxicol. 25: 711-5. PMID: 11765029
  3. The effect of deuterium and fluorine substitution upon the mutagenicity of N-hydroxy-2,6-dimethylaniline.  |  Matilde Marques, M., et al. 2002. Mutat Res. 506-507: 41-8. PMID: 12351143
  4. NTP Toxicology and Carcinogenesis Studies of 2,6-Xylidine (2,6-Dimethylaniline) (CAS No. 87-62-7) in Charles River CD Rats (Feed Studies).  |  ,. 1990. Natl Toxicol Program Tech Rep Ser. 278: 1-138. PMID: 12748701
  5. Chemical oxidation of 2,6-dimethylaniline by electrochemically generated Fenton's reagent.  |  Masomboon, N., et al. 2010. J Hazard Mater. 176: 92-8. PMID: 19963316
  6. Chemical oxidation of 2,6-dimethylaniline in the fenton process.  |  Masomboon, N., et al. 2009. Environ Sci Technol. 43: 8629-34. PMID: 20028063
  7. Effect of carrier composition on 2,6-dimethylaniline degradation in aqueous solution by fluidized-bed Fenton process.  |  Ratanatamskul, C., et al. 2011. Environ Technol. 32: 1233-7. PMID: 21970165
  8. Elevated 4-aminobiphenyl and 2,6-dimethylaniline hemoglobin adducts and increased risk of bladder cancer among lifelong nonsmokers--The Shanghai Bladder Cancer Study.  |  Tao, L., et al. 2013. Cancer Epidemiol Biomarkers Prev. 22: 937-45. PMID: 23539508
  9. Covalent binding of [14C]-2,6-dimethylaniline to DNA of rat liver and ethmoid turbinate.  |  Short, CR., et al. 1989. J Toxicol Environ Health. 27: 85-94. PMID: 2724370
  10. The in vivo oxidative metabolism of 2,4- and 2,6-dimethylaniline in the dog and rat.  |  Short, CR., et al. 1989. Toxicology. 57: 45-58. PMID: 2749743
  11. Muscle-Type Nicotinic Receptor Modulation by 2,6-Dimethylaniline, a Molecule Resembling the Hydrophobic Moiety of Lidocaine.  |  Alberola-Die, A., et al. 2016. Front Mol Neurosci. 9: 127. PMID: 27932949
  12. Measurement of lidocaine and 2,6-dimethylaniline in minipig plasma, skin, and dermal tapes using UHPLC with electrospray MS/MS.  |  Li, Q., et al. 2018. J Chromatogr B Analyt Technol Biomed Life Sci. 1087-1088: 158-172. PMID: 29747144
  13. Effect of 2,6-xylidine (DMA) on secretion of biomarkers for inflammation and neurodevelopment by the placenta.  |  Arita, Y., et al. 2022. J Reprod Immunol. 149: 103458. PMID: 34952372
  14. Forward and reverse dosimetry for aniline and 2,6-dimethylaniline in humans extrapolated from humanized-liver mouse data using simplified physiologically based pharmacokinetic models.  |  Miura, T., et al. 2022. J Toxicol Sci. 47: 531-538. PMID: 36450497
  15. 2,6-Dimethylaniline (2,6-xylidine).  |  . 1993. IARC Monogr Eval Carcinog Risks Hum. 57: 323-35. PMID: 8207863

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

2,6-Dimethylaniline, 5 g

sc-238422
5 g
$27.00

2,6-Dimethylaniline, 100 g

sc-238422A
100 g
$32.00