Molecular structure of Ferutinin, CAS Number: 41743-44-6
Ferutinin (CAS 41743-44-6)
See product citations (3)
Alternate Names:
Jaeschkeanadiol p-hydroxybenzoate; Tefestrol
Application:
Ferutinin is an ERα (estrogen receptor) agonist
CAS Number:
41743-44-6
Purity:
≥98%
Molecular Weight:
358.47
Molecular Formula:
C22H30O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Ferutinin is a potent, non-steroid estrogenic compound. It is an agonist for the estrogen receptor-α (ER alpha) and agonist/antagonist for ERbeta with higher binding affinity than tamoxifen for both ERs. It is also suggested as a modest acetylcholinesterase (AChE) inhibitor.
Ferutinin (CAS 41743-44-6) References
- The phytoestrogen ferutinin improves sexual behavior in ovariectomized rats. | Zavatti, M., et al. 2009. Phytomedicine. 16: 547-54. PMID: 19181505
- Structural and histomorphometric evaluations of ferutinin effects on the uterus of ovariectomized rats during osteoporosis treatment. | Ferretti, M., et al. 2012. Life Sci. 90: 161-8. PMID: 22100510
- Ferutinin dose-dependent effects on uterus and mammary gland in ovariectomized rats. | Ferretti, M., et al. 2014. Histol Histopathol. 29: 1027-37. PMID: 24510547
- Investigating anticancer properties of the sesquiterpene ferutinin on colon carcinoma cells, in vitro and in vivo. | Arghiani, N., et al. 2014. Life Sci. 109: 87-94. PMID: 24953605
- Estrogen receptor signaling in the ferutinin-induced osteoblastic differentiation of human amniotic fluid stem cells. | Zavatti, M., et al. 2016. Life Sci. 164: 15-22. PMID: 27629493
- Ferutinin Induces Membrane Depolarization, Permeability Transition Pore Formation, and Respiration Uncoupling in Isolated Rat Liver Mitochondria by Stimulation of Ca2+-Permeability. | Ilyich, T., et al. 2018. J Membr Biol. 251: 563-572. PMID: 29594529
- A ferutinin analogue with enhanced potency and selectivity against ER-positive breast cancer cells in vitro. | Safi, R., et al. 2018. Biomed Pharmacother. 105: 267-273. PMID: 29860218
- Ferula hermonis: A Review of Current Use and Pharmacological Studies of its Sesquiterpene Ester Ferutinin. | Safi, R., et al. 2020. Curr Drug Targets. 21: 499-508. PMID: 31663476
- Ferula L. Plant Extracts and Dose-Dependent Activity of Natural Sesquiterpene Ferutinin: From Antioxidant Potential to Cytotoxic Effects. | Macrì, R., et al. 2020. Molecules. 25: PMID: 33297504
- Ferutinin: A phytoestrogen from ferula and its anticancer, antioxidant, and toxicity properties. | Naji Reyhani Garmroudi, S., et al. 2021. J Biochem Mol Toxicol. 35: e22713. PMID: 33501774
- In vitro evaluation of ferutinin on proliferation and osteogenesis differentiation in human unrestricted Somatic stem cells. | Mahmoudi, Z., et al. 2021. Steroids. 172: 108862. PMID: 34010709
- Screening of natural compounds identifies ferutinin as an antibacterial and anti-biofilm compound. | Gilbert-Girard, S., et al. 2021. Biofouling. 37: 791-807. PMID: 34455871
- Ferutinin induces osteoblast differentiation of DPSCs via induction of KLF2 and autophagy/mitophagy. | Maity, J., et al. 2022. Cell Death Dis. 13: 452. PMID: 35552354
Inhibitor of:
AChE.Activator of:
ER alpha.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ferutinin, 1 mg | sc-221610 | 1 mg | $37.00 | |||
Ferutinin, 5 mg | sc-221610A | 5 mg | $105.00 |