Molecular structure of Acetaminophen, CAS Number: 103-90-2
Acetaminophen (CAS 103-90-2)
See product citations (11)
Alternate Names:
4′-Hydroxyacetanilide; 4-Acetamidophenol; Paracetamol
Application:
Acetaminophen is a Cox-1, Cox-2, and Cox-3 (cyclooxygenase) inhibitor
CAS Number:
103-90-2
Purity:
≥98%
Molecular Weight:
151.16
Molecular Formula:
C8H9NO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Acetaminophen is a compound widely used in various research areas, particularly in the study of its mechanism of action and the metabolic pathways it undergoes. Researchers focus on its interaction with the enzyme systems, where it is metabolized through conjugation and oxidative pathways. In the field of toxicology, acetaminophen is a model compound for the study of oxidative stress and the role of glutathione in hepatocyte protection, due to its well-documented metabolite-mediated hepatotoxicity at high doses. This compound′s reactivity with protein thiol groups is also of interest in research on the modulation of protein function and the implications of covalent modification. Additionally, acetaminophen serves as a reference standard in the development and validation of analytical methods such as high-performance liquid chromatography (HPLC) and mass spectrometry for the quantification and monitoring of compounds in biological matrices.
Acetaminophen (CAS 103-90-2) References
- Determination of paracetamol (acetaminophen) in different body fluids and organ samples after solid-phase extraction using HPLC and an immunological method. | Pufal, E., et al. 2000. Fresenius J Anal Chem. 367: 596-9. PMID: 11225839
- The effects of additives on the growth and morphology of paracetamol (acetaminophen) crystals. | Thompson, C., et al. 2004. Int J Pharm. 280: 137-50. PMID: 15265554
- Metabolism of acetaminophen (paracetamol) in plants--two independent pathways result in the formation of a glutathione and a glucose conjugate. | Huber, C., et al. 2009. Environ Sci Pollut Res Int. 16: 206-13. PMID: 19145453
- The effect of different doses of flumazenil on acetaminophen toxicity in rats. | Bozogluer, E., et al. 2012. Bratisl Lek Listy. 113: 525-8. PMID: 22979906
- NQO2 is a reactive oxygen species generating off-target for acetaminophen. | Miettinen, TP. and Björklund, M. 2014. Mol Pharm. 11: 4395-404. PMID: 25313982
- Metabolism by conjugation appears to confer resistance to paracetamol (acetaminophen) hepatotoxicity in the cynomolgus monkey. | Yu, H., et al. 2015. Xenobiotica. 45: 270-7. PMID: 25335570
- Simultaneous quantification of acetaminophen and five acetaminophen metabolites in human plasma and urine by high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry: Method validation and application to a neonatal pharmacokinetic study. | Cook, SF., et al. 2015. J Chromatogr B Analyt Technol Biomed Life Sci. 1007: 30-42. PMID: 26571452
- Paracetamol (acetaminophen) protein adduct concentrations during therapeutic dosing. | Heard, K., et al. 2016. Br J Clin Pharmacol. 81: 562-8. PMID: 26584404
- Bioinorganic Nanohybrid Catalyst for Multistep Synthesis of Acetaminophen, an Analgesic. | San, BH., et al. 2016. ACS Appl Mater Interfaces. 8: 30058-30065. PMID: 27797174
- Deriving harmonised permitted daily exposures (PDEs) for paracetamol (acetaminophen) CAS #: 103-90-2. | Gromek, K., et al. 2020. Regul Toxicol Pharmacol. 115: 104692. PMID: 32522580
- Effects of paracetamol (acetaminophen) on gene expression and permeability properties of the rat placenta and fetal brain. | Koehn, LM., et al. 2020. F1000Res. 9: 573. PMID: 32934805
- Long-term administration of toxic doses of paracetamol (acetaminophen) to rats. | Poulsen, HE. and Thomsen, P. 1988. Liver. 8: 151-6. PMID: 3393065
- Optimization of gradient reversed phase high performance liquid chromatography analysis of acetaminophen oxidation metabolites using linear and non-linear retention model. | Vanova, J., et al. 2022. J Chromatogr A. 1669: 462956. PMID: 35306469
- Effect of acetaminophen (paracetamol) and its antagonists on glutathione (GSH) content in rat liver. | Viña, J., et al. 1980. Biochem Pharmacol. 29: 1968-70. PMID: 7397003
Inhibitor of:
1700055N04Rik, ADH5, AKR1C20, Alox12e, C9orf21, carbonyl reductase 2, CHST7, Cox, Cox-2, cytochrome b5, D11Wsu47e, DDTL, DFNB59, DHDH, EG436003, F830116E18Rik, GCL, Glutathione, Gm13247, Gm14139, Gm14306, GNMT, GSH-1, GSTM3, Histatin 2, HS3ST4, IFN-α9, Igkv3-4, LHFPL5, LZIP, MPST, MUP15, NAT-2, PBGD, PGD synthase, PGE Synthase, PGE synthase 2, Prealbumin, PTG, RDH2, SULT1A3, and TRAX.Activator of:
AIM2, AKR1B7, BACH2, Bicoid, CD35_Curry, Ces1c, Ces1d, CYP1A1, CYP4A29, CYP4A30B, DnaJC5γ, EG215895, EG619597, ELOVL7, galectin-10, GCSH, GLOD5, IL-8RB, MCP-3, PPIAL4G, PRX IV, SCAMP4, SDR39U1, SULT1A1, SULT1C1, and VAP-B/C.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Acetaminophen, 5 g | sc-203425 | 5 g | $40.00 | |||
Acetaminophen, 100 g | sc-203425A | 100 g | $60.00 | |||
Acetaminophen, 500 g | sc-203425B | 500 g | $190.00 |