Molecular structure of Polygodial, CAS Number: 6754-20-7
Polygodial (CAS 6754-20-7)
See product citations (5)
Alternate Names:
(1R,4aS,8aS)-1,4,4a,5,6,7,8,8a-Octahydro-5,5,8a-trimethyl-1,2-naphthalenedicarboxaldehyde
Application:
Polygodial is a naturally occurring antifungal and antinociceptive
CAS Number:
6754-20-7
Purity:
97%
Molecular Weight:
234.33
Molecular Formula:
C15H22O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Polygodial is a compound that functions as a bioactive agent in experimental applications. It interacts with specific molecular targets, particularly ion channels and receptors, modulating their activity. Polygodial may exhibit potent insecticidal and antimicrobial properties, making it useful for investigating biological processes and potential applications in various fields. Polygodial′s mechanism of action involves disrupting cellular functions and signaling pathways, ultimately leading to physiological effects in experimental models. Its ability to interact with specific molecular targets may be an intriguing compound for further development in various scientific disciplines.
Polygodial (CAS 6754-20-7) References
- Effect of polygodial on the mitochondrial ATPase of Saccharomyces cerevisiae. | Lunde, CS. and Kubo, I. 2000. Antimicrob Agents Chemother. 44: 1943-53. PMID: 10858359
- Protective effects of polygodial and related compounds on ethanol-induced gastric mucosal lesions in rats: structural requirements and mode of action. | Matsuda, H., et al. 2002. Bioorg Med Chem Lett. 12: 477-82. PMID: 11814823
- Evidence for the involvement of vanilloid receptor in the antinociception produced by the dialdeydes unsaturated sesquiterpenes polygodial and drimanial in rats. | Andre, E., et al. 2004. Neuropharmacology. 46: 590-7. PMID: 14975683
- Inhibition of the mitochondrial ATP synthesis by polygodial, a naturally occurring dialdehyde unsaturated sesquiterpene. | Castelli, MV., et al. 2005. Biochem Pharmacol. 70: 82-9. PMID: 15894293
- Antifungal activity of drimane sesquiterpenes from Drimys brasiliensis using bioassay-guided fractionation. | Malheiros, A., et al. 2005. J Pharm Pharm Sci. 8: 335-9. PMID: 16124945
- The sesquiterpenes polygodial and drimanial in vitro affect glutamatergic transport in rat brain. | Martini, LH., et al. 2006. Neurochem Res. 31: 431-8. PMID: 16733820
- Polygodial, a sesquiterpene isolated from Drimys brasiliensis (Winteraceae), triggers glucocorticoid-like effects on pancreatic β-cells. | Barrosa, KH., et al. 2016. Chem Biol Interact. 258: 245-56. PMID: 27645309
- Antifungal Effect of Polygodial on Botrytis cinerea, a Fungal Pathogen Affecting Table Grapes. | Carrasco, H., et al. 2017. Int J Mol Sci. 18: PMID: 29077000
- Polygodial analog induces apoptosis in LNCaP prostate cancer cells. | Dasari, S., et al. 2018. Eur J Pharmacol. 828: 154-162. PMID: 29572068
- Effect of polygodial and its direct derivatives on the mammalian Na+/K+-ATPase activity. | Garcia, DG., et al. 2018. Eur J Pharmacol. 831: 1-8. PMID: 29715454
- Investigating the Antifungal Mechanism of Action of Polygodial by Phenotypic Screening in Saccharomyces cerevisiae. | Kipanga, PN., et al. 2021. Int J Mol Sci. 22: PMID: 34071169
- Polygodial, a drimane sesquiterpenoid dialdehyde purified from Drimys winteri, inhibits voltage-gated sodium channels. | Paz, C., et al. 2022. Nat Prod Res. 36: 6318-6323. PMID: 35021940
- Action of polygodial, a sesquiterpene isolated from Drymis winteri, in the guinea-pig ileum and trachea 'in vitro'. | El Sayah, M., et al. 1998. Eur J Pharmacol. 344: 215-21. PMID: 9600657
Inhibitor of:
ATP5.Activator of:
ANKTM1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Polygodial, 5 mg | sc-201489 | 5 mg | $117.00 | |||
Polygodial, 25 mg | sc-201489A | 25 mg | $444.00 |