Molecular structure of Galanthamine Hydrobromide, CAS Number: 1953-04-4
Galanthamine Hydrobromide (CAS 1953-04-4)
See product citations (2)
Alternate Names:
Nivalin;Razadyne
Application:
Galanthamine Hydrobromide is a competitive and reversible acetylcholinesterase inhibitor
CAS Number:
1953-04-4
Purity:
≥98%
Molecular Weight:
368.27
Molecular Formula:
C17H21NO3•HBr
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Galanthamine Hydrobromide is a competitive and reversible AChE (acetylcholinesterase) inhibitor, which displays allosteric potentiating effects at nicotinic receptors. In addition, Galanthamine Hydrobromide affects cholinergic transmission and the release of neurotransmitters such as monoamines, glutamate, and γ-aminobutyric acid (GABA). As a result of its inhibitory effects on acetylcholinesterase, Galanthamine Hydrobromide increases the concentration of acetylcholine in the brain.
Galanthamine Hydrobromide (CAS 1953-04-4) References
- Galantamine hydrobromide: an agent for Alzheimer's disease. | Zarotsky, V., et al. 2003. Am J Health Syst Pharm. 60: 446-52. PMID: 12635450
- Effects of four non-cholinergic cognitive enhancers in comparison with tacrine and galanthamine on scopolamine-induced amnesia in rats. | Chopin, P. and Briley, M. 1992. Psychopharmacology (Berl). 106: 26-30. PMID: 1738791
- Galanthamine treatment in Alzheimer's disease. | Dal-Bianco, P., et al. 1991. J Neural Transm Suppl. 33: 59-63. PMID: 1753253
- Inhibition of acetylcholinesterase activity in human brain tissue and erythrocytes by galanthamine, physostigmine and tacrine. | Thomsen, T., et al. 1991. Eur J Clin Chem Clin Biochem. 29: 487-92. PMID: 1954303
- Cholinergic influence on memory facilitation induced by angiotensin II in rats. | Yonkov, DI. and Georgiev, VP. 1990. Neuropeptides. 16: 157-62. PMID: 1964494
- Pharmacological aspects of the acetylcholinesterase inhibitor galantamine. | Ago, Y., et al. 2011. J Pharmacol Sci. 116: 6-17. PMID: 21498956
- In Salvia miltiorrhiza, phenolic acids possess protective properties against amyloid β-induced cytotoxicity, and tanshinones act as acetylcholinesterase inhibitors. | Zhou, Y., et al. 2011. Environ Toxicol Pharmacol. 31: 443-52. PMID: 21787715
- Benzophenones from Hypericum elegans with antioxidant and acetylcholinesterase inhibitory potential. | Zheleva-Dimitrova, D., et al. 2013. Pharmacogn Mag. 9: S1-5. PMID: 24143038
- Acetylcholinesterase inhibitor treatment alleviated cognitive impairment caused by delayed encephalopathy due to carbon monoxide poisoning: Two case reports and a review of the literature. | Yanagiha, K., et al. 2017. Medicine (Baltimore). 96: e6125. PMID: 28225493
- [The Regulation of AMPKα1/Nrf2/ HO-1 Pathway Mediated by Galantamine Hydrobromide Lycoremine in Myocardial Ischemia Reperfusion Rats]. | Zeng, F., et al. 2020. Sichuan Da Xue Xue Bao Yi Xue Ban. 51: 337-343. PMID: 32543139
- Liposome Loaded Ion/Temperature Dual Responsive Gellan Gum Hydrogel as Potential Nasal-To-Brain Delivery System. | Zhou, S., et al. 2022. J Biomed Nanotechnol. 18: 571-580. PMID: 35484743
- Gastrointestinal loss of galanthamine hydrobromide in rats in-situ. | Yamboliev, I., et al. 1993. J Pharm Pharmacol. 45: 763-5. PMID: 7901379
- Nivalin P-induced changes in muscle fiber membrane processes. | Radicheva, N., et al. 1996. Methods Find Exp Clin Pharmacol. 18: 301-8. PMID: 8817464
Inhibitor of:
AChE.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Galanthamine Hydrobromide, 25 mg | sc-200179 | 25 mg | $60.00 | |||
Galanthamine Hydrobromide, 100 mg | sc-200179A | 100 mg | $170.00 |