ZNF705D Inhibitors
The chemical class of ZNF705D inhibitors comprises a diverse array of compounds that target various signaling pathways and cellular processes involved in the regulation of ZNF705D expression and activity. ZNF705D, a zinc finger transcription factor, plays a crucial role in gene regulation and cellular functions. To modulate ZNF705D activity, researchers have identified a range of small molecules that target key cellular pathways and processes associated with its function.
One group of inhibitors includes those that target epigenetic regulators, such as histone deacetylases (HDACs) and bromodomain-containing proteins (BRDs). For example, Dacinostat and JQ1 inhibit HDACs and BRD4, respectively, leading to alterations in chromatin structure and transcriptional activity, which can indirectly impact ZNF705D expression and function. Additionally, inhibitors targeting protein degradation pathways, such as MLN4924 and Bortezomib, disrupt protein homeostasis and stability, potentially affecting ZNF705D protein levels.
Another class of inhibitors includes those that modulate key signaling pathways implicated in gene regulation and cellular processes, such as the NF-κB, Wnt, and p53 signaling pathways. Compounds like TPCA-1, LGK-974, and Nutlin-3 inhibit IKK-2, Porcupine, and MDM2, respectively, leading to alterations in downstream signaling cascades that can indirectly regulate ZNF705D expression. Furthermore, inhibitors targeting cellular kinases, such as Trifluoperazine, AICAR, and Rigosertib, modulate kinase-mediated signaling pathways involved in cell cycle regulation and energy metabolism, potentially impacting ZNF705D activity through downstream signaling events. Collectively, the chemical class of ZNF705D inhibitors provides valuable tools for dissecting the molecular mechanisms underlying ZNF705D function.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $226.00 $846.00 | 1 | |
JQ1 is a selective inhibitor of bromodomain-containing protein 4 (BRD4), which can indirectly inhibit ZNF705D by preventing its interaction with acetylated histones, thereby suppressing its transcriptional activity. | ||||||
Nutlin-3 | 548472-68-0 | sc-45061 sc-45061A sc-45061B | 1 mg 5 mg 25 mg | $56.00 $212.00 $764.00 | 24 | |
Nutlin-3 inhibits the interaction between p53 and its negative regulator, MDM2, leading to the stabilization and activation of p53, which can indirectly suppress ZNF705D expression by activating downstream p53 signaling pathways. | ||||||
MLN 4924 | 905579-51-3 | sc-484814 | 1 mg | $280.00 | 1 | |
MLN4924 inhibits neddylation, a post-translational modification process, thereby blocking the activity of cullin-RING E3 ubiquitin ligases (CRLs), which can indirectly affect ZNF705D protein stability and degradation. | ||||||
Trifluoperazine Dihydrochloride | 440-17-5 | sc-201498 sc-201498A | 1 g 5 g | $56.00 $99.00 | 9 | |
Trifluoperazine is a calmodulin antagonist that inhibits calmodulin-dependent protein kinase II (CaMKII), a kinase involved in various signaling pathways, which can indirectly modulate ZNF705D activity. | ||||||
IKK-2 Inhibitor IV | 507475-17-4 | sc-203083 | 500 µg | $130.00 | 12 | |
TPCA-1 inhibits IκB kinase-2 (IKK-2), a kinase involved in the NF-κB signaling pathway, which can indirectly regulate ZNF705D expression by modulating NF-κB-mediated transcriptional activity. | ||||||
LGK 974 | 1243244-14-5 | sc-489380 sc-489380A | 5 mg 50 mg | $352.00 $1270.00 | 2 | |
LGK-974 is a selective inhibitor of the Wnt signaling pathway by targeting Porcupine, an enzyme required for Wnt ligand secretion, which can indirectly influence ZNF705D expression by modulating Wnt signaling. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Bortezomib inhibits the proteasome, a cellular protein degradation complex, leading to the accumulation of ubiquitinated proteins and the disruption of protein homeostasis, which can indirectly affect ZNF705D protein levels. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $60.00 $270.00 $350.00 | 48 | |
AICAR is an AMP-activated protein kinase (AMPK) activator that can modulate cellular energy metabolism and signaling pathways, potentially impacting ZNF705D activity through AMPK-mediated signaling cascades. | ||||||
VE 821 | 1232410-49-9 | sc-475878 | 10 mg | $360.00 | ||
VX-11e is a potent inhibitor of dual-specificity tyrosine phosphorylation-regulated kinase 2 (DYRK2), which regulates various cellular processes, including protein degradation and cell cycle progression, potentially impacting ZNF705D activity. | ||||||