WDR18 Inhibitors

WDR18 inhibitors are a class of chemicals that primarily aim to target the functions and pathways WDR18 is known to be involved in. This is especially relevant for ribosomal biogenesis and DNA damage repair pathways, among other cellular processes. Chemicals such as Rapamycin and Actinomycin D inhibit the ribosome biogenesis pathway by affecting mTOR signaling and RNA polymerase activity, respectively. This means that they have to directly attenuate the functional roles of WDR18 in ribosome production. On the other hand, Cisplatin and Camptothecin disrupt DNA structures and act as direct obstacles to DNA damage repair mechanisms.

Another aspect to consider is the involvement of WDR18 in complex cellular pathways, such as DNA repair, ribosome biogenesis, and chromosomal segregation. Chemicals like ZM 447439 and Bortezomib target the Aurora kinase and the proteasome complex respectively. Aurora kinase is vital for chromosomal segregation, and its inhibition can lead to disruption of pathways involving WDR18. Proteasome inhibition by Bortezomib can affect the stability and turnover of proteins, thereby affecting pathways that WDR18 is part of.