Veli2 Activators
Chemical classes identified as VELI2 activators are a diverse group of compounds that have been found to influence various cellular signaling pathways and processes which VELI2 is known to be a part of. These activators function by modulating the activity of VELI2 indirectly, through the alteration of cellular environments and the activation of signaling cascades that VELI2 is associated with. The compounds that fall into this category achieve this by engaging with different molecular targets within the cell, leading to a series of downstream effects that can facilitate the functional roles of VELI2 in synaptic assembly, neurotransmitter receptor localization, cell polarity, and vesicular trafficking. Given the scaffolding nature of VELI2, the activation by these compounds does not imply a direct enhancement of enzymatic activity but rather an upregulation or facilitation of VELI2's participation in critical cellular functions.
These activators encompass a range of molecules that interact with various cellular components. Some of these compounds are known to enhance the levels of secondary messengers within the cell, thereby activating kinases that phosphorylate proteins in close proximity or associated with VELI2, modifying its interaction with other proteins and its localization within the cell. Others interact with the cytoskeletal elements of the cell, altering the dynamics of the cytoskeleton and influencing the transport and positioning of vesicles and membrane proteins, which in turn can affect the processes where VELI2 is a significant player. Additionally, certain compounds in this class can modulate gene expression profiles or protein stability, thereby adjusting the cellular concentration of proteins that work in conjunction with VELI2, thus modulating its activity. Through these diverse mechanisms, the chemical classes referred to as VELI2 activators encompass a variety of compounds that, by influencing signaling pathways or cellular structures, can support the functional roles attributed to VELI2.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylyl cyclase, which increases cAMP levels leading to PKA activation. PKA can phosphorylate proteins related to the synaptic machinery, which could possibly activate Veli2'S synaptic assembly and neurotransmitter receptor localization functions. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which could possibly activate Veli2 by influencing cell polarity and synaptic plasticity. PKC-mediated phosphorylation might affect proteins associated with Veli2, altering its function in cellular processes. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid can influence neuronal differentiation and synaptogenesis, which could possibly activate Veli2'S role in synaptic organization. | ||||||
Wnt Agonist | 853220-52-7 | sc-222416 sc-222416A | 5 mg 25 mg | $154.00 $597.00 | 23 | |
This compound activates the Wnt signaling pathway, which could possibly activate Veli2 by influencing its synaptic functions. | ||||||
Adenosine 3′,5′-cyclic monophosphate | 60-92-4 | sc-217584 sc-217584A sc-217584B sc-217584C sc-217584D sc-217584E | 100 mg 250 mg 5 g 10 g 25 g 50 g | $114.00 $175.00 $260.00 $362.00 $617.00 $1127.00 | ||
An analog of cAMP that permeates cell membranes and activates PKA, which could possibly activate Veli2 by altering phosphorylation states of related proteins. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
As a tyrosine kinase inhibitor, Genistein could possibly activate Veli2 by modulating various signaling pathways that affect cell polarity and synaptic organization. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Nocodazole disrupts microtubules, which could possibly activate Veli2 by affecting vesicle trafficking and cell polarity, potentially altering Veli2'S cellular context and function. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $145.00 $442.00 | 64 | |
Cytochalasin D inhibits actin polymerization, which could possibly activate Veli2 by leading to changes in cell shape and polarity, influencing the distribution and function of Veli2 in the cell. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
As a calcium ionophore, Ionomycin raises intracellular calcium levels, which could possibly activate Veli2 by influencing synaptic function and plasticity. | ||||||