V1RC13 Activators
Chemical activators of V1RC13 manipulate intracellular signaling pathways to achieve the protein's activation. Forskolin, Isoproterenol, Adrenaline, Dopamine, ATP, Nicotine, Serotonin, and Norepinephrine each engage in a similar process whereby they bind to their respective receptors and stimulate adenylate cyclase activity, which leads to a rise in cyclic AMP (cAMP) levels within the cell. The increase in cAMP activates protein kinase A (PKA), which then phosphorylates V1RC13, resulting in its activation. This phosphorylation step is critical as it leads to changes in the protein's structure and function, enabling it to carry out its role in the cell.
In contrast, Histamine, Acetylcholine, Glutamate, and Capsaicin activate V1RC13 through a different mechanism. These chemicals bind to their respective receptors that are coupled to G proteins, leading to the activation of phospholipase C (PLC). PLC facilitates the production of inositol triphosphate (IP3) and diacylglycerol (DAG), which promote the release of calcium from intracellular stores. The released calcium ions then activate protein kinase C (PKC). In the case of Capsaicin, it acts through the TRPV1 receptor, which directly allows calcium influx, leading to activation of calcium-calmodulin kinase II (CaMKII). Both PKC and CaMKII, once activated, can phosphorylate V1RC13, culminating in its activation. Each chemical, by engaging with its specific receptor and downstream signaling molecules, ensures that V1RC13 is activated and can participate in the necessary cellular functions.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol binds to and activates beta-adrenergic receptors, which in turn stimulate adenylate cyclase activity, raising cAMP levels. Elevated cAMP activates PKA, which may then phosphorylate V1RC13, leading to its activation. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Adrenaline interacts with adrenergic receptors, specifically the beta subtype, which leads to adenylate cyclase activation. This causes an increase in cAMP and activation of PKA, which subsequently phosphorylates and activates V1RC13. | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
Dopamine binds to its G protein-coupled receptors, leading to the activation of adenylate cyclase and an increase in cAMP. This rise in cAMP levels activates PKA, which can phosphorylate and activate V1RC13. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $94.00 $283.00 $988.00 | 7 | |
Histamine binds to H1 receptors, which can activate phospholipase C (PLC). PLC increases the production of inositol triphosphate (IP3) and diacylglycerol (DAG), leading to calcium release and activation of protein kinase C (PKC). PKC can then activate V1RC13. | ||||||
ADP | 58-64-0 | sc-507362 | 5 g | $54.00 | ||
ATP binds to purinergic receptors, which can lead to either adenylate cyclase activation via Gs proteins, increasing cAMP, or the activation of PLC via Gq proteins. Both pathways involve kinases such as PKA or PKC that can activate V1RC13. | ||||||
L-Glutamic Acid | 56-86-0 | sc-394004 sc-394004A | 10 g 100 g | $297.00 $577.00 | ||
Glutamate acts on metabotropic glutamate receptors linked to Gq proteins, activating PLC. This increases IP3 and DAG, causing calcium release and activation of PKC, which can then activate V1RC13. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $96.00 $160.00 $240.00 $405.00 | 26 | |
Capsaicin binds to TRPV1 receptors, causing calcium influx. The elevated intracellular calcium can activate calcium-calmodulin kinase II (CaMKII), which may then phosphorylate and functionally activate V1RC13. | ||||||
Serotonin hydrochloride | 153-98-0 | sc-201146 sc-201146A | 100 mg 1 g | $118.00 $187.00 | 15 | |
Serotonin binds to 5-HT receptors, some of which are coupled to Gs proteins that activate adenylate cyclase, increasing cAMP. Higher cAMP levels activate PKA, which can phosphorylate and activate V1RC13. | ||||||
L-Noradrenaline | 51-41-2 | sc-357366 sc-357366A | 1 g 5 g | $326.00 $485.00 | 3 | |
Norepinephrine interacts with adrenergic receptors, particularly beta receptors, leading to the activation of adenylate cyclase and an increase in cAMP. The rise in cAMP activates PKA, which phosphorylates and activates V1RC13. | ||||||