UGT2B Activators

The chemical class of UGT2B Activators encompasses compounds that can indirectly influence the activity of UGT2B through their effects on liver function, metabolic enzyme regulation, and detoxification pathways. These compounds do not directly activate UGT2B enzymes; instead, they modulate physiological and metabolic conditions that could enhance UGT2B's functional role in glucuronidation.

Compounds such as Phenobarbital, Rifampicin, Oltipraz, and Sulforaphane are known to induce liver enzymes, including phase II detoxifying enzymes, potentially leading to increased UGT2B activity. Curcumin, Resveratrol, and Dexamethasone, through their varied effects on liver metabolism and enzyme expression, could also influence UGT2B's function. Additionally, natural compounds like St. John's Wort, Capsaicin, Indole-3-carbinol, Ellagic Acid, and Naringenin are known to modulate liver enzyme activity. Their influence on metabolic pathways could indirectly enhance the activity of UGT2B enzymes involved in drug metabolism and detoxification.