TTC30A Inhibitors
Chemical inhibitors of the TTC30A protein operate through various mechanisms to disrupt the normal function of TTC30A, which plays a pivotal role in ciliogenesis and the regulation of ciliary beat frequency. These inhibitors target the microtubule structures that are essential for the proper assembly and function of cilia, where TTC30A is localized and exerts its function. Colchicine, for instance, binds to tubulin and prevents its polymerization, effectively hindering the formation of microtubules. Such an action directly affects the TTC30A protein's ability to participate in cilia assembly, as the structural integrity of cilia is compromised. Similar to colchicine, podophyllotoxin also binds to tubulin, thwarting its polymerization and thus the assembly of microtubules that form the backbone of cilia.
Moreover, while some inhibitors like paclitaxel and epothilone B stabilize microtubules and prevent their depolymerization, this stabilization is detrimental to the dynamic instability required for the proper functioning of TTC30A. Other chemicals, such as nocodazole, vinblastine, and vincristine, interfere with tubulin and microtubule assembly, which are critical for the TTC30A protein's role in ciliogenesis. Nocodazole inhibits microtubule polymerization, whereas vinblastine and vincristine bind to tubulin dimers, obstructing microtubule formation. Griseofulvin, by interacting with polymerized microtubules, alters their function, which is crucial for TTC30A's involvement in ciliary movement. Additionally, compounds like albendazole, mebendazole, and thiabendazole target tubulin to inhibit microtubule polymerization, which is necessary for the maintenance of cilia where TTC30A is active. Oryzalin also disrupts microtubule organization by binding to tubulin dimers, preventing the assembly of microtubules and thus impeding the TTC30A protein's function. Each of these chemical inhibitors, by affecting the microtubule dynamics, can impede the activity of TTC30A, leading to disruptions in ciliary assembly and function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $98.00 $315.00 $2244.00 $4396.00 $17850.00 $34068.00 | 3 | |
Colchicine binds to tubulin, a structural component of microtubules, leading to the inhibition of microtubule polymerization. TTC30A is involved in cilia assembly and function, which is dependent on microtubule dynamics. Inhibition of tubulin affects ciliary function where TTC30A operates. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
Paclitaxel stabilizes microtubules and prevents their depolymerization, which can disrupt microtubule dynamics necessary for ciliary movement and function. TTC30A's role in ciliogenesis and ciliary beat frequency can be inhibited by altered microtubule dynamics. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Nocodazole disrupts microtubule networks by inhibiting their polymerization. Since TTC30A functions in ciliary movement that relies on intact microtubules, nocodazole's mechanism directly inhibits TTC30A's role in ciliogenesis. | ||||||
Podophyllotoxin | 518-28-5 | sc-204853 | 100 mg | $82.00 | 1 | |
Podophyllotoxin binds to tubulin and inhibits its polymerization. By preventing microtubule assembly, it can inhibit TTC30A activity which is crucial for the proper formation and function of cilia, structures that are dependent on microtubules. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $100.00 $230.00 $450.00 $1715.00 $2900.00 | 4 | |
Vinblastine interferes with microtubule assembly by binding to tubulin, which can inhibit TTC30A activity as TTC30A is implicated in the ciliogenesis process that requires properly assembled microtubules. | ||||||
Griseofulvin | 126-07-8 | sc-202171A sc-202171 sc-202171B | 5 mg 25 mg 100 mg | $83.00 $216.00 $586.00 | 4 | |
Griseofulvin disrupts microtubule function by interacting with polymerized microtubules. This can inhibit TTC30A function by altering the microtubule structures that are essential for ciliary assembly and movement. | ||||||
Epothilone B, Synthetic | 152044-54-7 | sc-203944 | 2 mg | $176.00 | ||
Epothilone B stabilizes microtubules in a manner similar to paclitaxel, preventing their disassembly. This stabilization negatively impacts the dynamic instability of microtubules necessary for ciliogenesis, thus inhibiting TTC30A function. | ||||||
Thiabendazole | 148-79-8 | sc-204913 sc-204913A sc-204913B sc-204913C sc-204913D | 10 g 100 g 250 g 500 g 1 kg | $31.00 $82.00 $179.00 $306.00 $561.00 | 5 | |
Thiabendazole interferes with microtubule polymerization. Since TTC30A is involved in the assembly and maintenance of cilia which are dependent on microtubules, inhibition of microtubule polymerization can inhibit the function of TTC30A. | ||||||
Albendazole | 54965-21-8 | sc-210771 | 100 mg | $209.00 | 1 | |
Albendazole targets tubulin and microtubule formation. This leads to an inhibition of microtubule polymerization, which can in turn inhibit TTC30A activity by disrupting the microtubule-dependent processes of ciliogenesis and ciliary function. | ||||||
Mebendazole | 31431-39-7 | sc-204798 sc-204798A | 5 g 25 g | $45.00 $87.00 | 2 | |
Mebendazole specifically targets the microtubule formation in cells, leading to an inhibition of their assembly. TTC30A, which is crucial for ciliary structure and function, relying on intact microtubules, can be functionally inhibited by mebendazole's action. | ||||||