Date published: 2026-2-22

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TRPV1 Activators

Santa Cruz Biotechnology now offers a broad range of TRPV1 Activators for use in various applications. TRPV1 Activators are a category of chemicals that specifically interact with the transient receptor potential vanilloid 1 (TRPV1), a protein widely studied in sensory neuroscience. These activators are invaluable tools in scientific research, enabling researchers to explore the mechanisms of pain perception, temperature regulation, and neurogenic inflammation. By selectively binding to and activating the TRPV1 channel, these chemicals facilitate the study of complex physiological responses at a molecular level, providing insights into cellular signaling pathways and receptor dynamics. TRPV1 Activators are utilized in various experimental setups, including electrophysiology, imaging studies, and biochemical assays, to study the role of TRPV1 in cellular and systemic functions. They are also crucial in developing and testing new models of nociception and inflammation, thus advancing our understanding of these processes in normal and disease states. The precise modulation of TRPV1 activity through these activators helps in dissecting the contributions of this receptor in different tissues and organisms, making them essential in a wide array of research fields, including neurobiology and physiology. View detailed information on our available TRPV1 Activators by clicking on the product name.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Eugenol

97-53-0sc-203043
sc-203043A
sc-203043B
1 g
100 g
500 g
$32.00
$62.00
$218.00
2
(1)

Eugenol acts as a modulator of TRPV1 channels, exhibiting unique hydrophobic interactions that enhance receptor sensitivity to thermal stimuli. Its molecular structure allows for specific conformational changes in the channel, influencing ion permeability and activation dynamics. The compound's rapid binding kinetics facilitate immediate responses, while its ability to interact with lipid membranes may alter local microenvironments, further affecting TRPV1 signaling pathways.

AM 404

183718-77-6sc-207275
10 mg
$118.00
(0)

AM 404 is a selective modulator of TRPV1 channels, characterized by its ability to form hydrogen bonds with key amino acid residues, which stabilizes the receptor's active conformation. This compound exhibits a unique affinity for lipid bilayers, potentially altering membrane fluidity and impacting channel activation. Its interaction with TRPV1 is marked by a distinct allosteric modulation, influencing ion flow and receptor desensitization kinetics, thereby affecting sensory signaling pathways.