TRAP230 Inhibitors
TRAP230, also known as MED12 (Mediator Complex Subunit 12), is a component of the mediator complex, a multi-protein assembly crucial for the regulation of gene transcription. The mediator complex acts as a bridge between DNA-binding transcription factors and RNA polymerase II, facilitating the transcription of DNA into RNA. TRAP230/MED12 plays a pivotal role within this complex, helping modulate its interaction with various transcription factors and influencing the transcriptional regulation of numerous genes. Given the significance of gene regulation in myriad cellular processes, MED12 and the mediator complex at large are fundamental to ensuring appropriate cellular functions.
TRAP230 Inhibitors refer to a class of compounds designed to diminish or halt the activity of TRAP230/MED12. Such inhibition can disrupt the proper functioning of the mediator complex, potentially leading to altered transcriptional landscapes within the cell. The specific mechanisms through which these inhibitors operate could vary. Some might bind directly to TRAP230/MED12, altering its conformation or its ability to interact with other components of the mediator complex. Others might act indirectly, perhaps by modulating upstream or downstream signaling pathways that influence TRAP230/MED12 activity. Additionally, post-translational modifications of TRAP230/MED12 could be targeted to modify its function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
THZ1 | 1604810-83-4 | sc-507542 | 1 mg | $95.00 | ||
THZ1 is a highly potent and selective MED12 inhibitor that targets the kinase activity of CDK7, a component of the Mediator complex. It has shown promise in research studies against various cancer types. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $231.00 $863.00 | 1 | |
Although primarily known as a BET bromodomain inhibitor, JQ1 has also been found to inhibit MED12 by disrupting its interaction with BRD4, a mediator of transcriptional elongation. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $90.00 $204.00 | 13 | |
Triptolide is a natural compound found in the Thunder God Vine (Tripterygium wilfordii). It inhibits MED12 by binding to its ATPase domain, thereby interfering with the function of the Mediator complex. | ||||||
H-89 dihydrochloride | 130964-39-5 | sc-3537 sc-3537A | 1 mg 10 mg | $94.00 $186.00 | 71 | |
Originally developed as a PKA inhibitor, H-89 has been found to inhibit MED12 by targeting its kinase activity. It has shown potential as an anti-cancer agent in research studies. | ||||||
RO-3306 | 872573-93-8 | sc-358700 sc-358700A sc-358700B | 1 mg 5 mg 25 mg | $66.00 $163.00 $326.00 | 37 | |
Ro-3306 is a selective inhibitor of CDK1, a member of the cyclin-dependent kinase family. By targeting CDK1, Ro-3306 indirectly inhibits MED12 activity, resulting in altered gene expression. | ||||||
XMD 8-92 (free base) | 1234480-50-2 | sc-364068 sc-364068A sc-364068B sc-364068C | 5 mg 10 mg 100 mg 1 g | $235.00 $340.00 $1700.00 $10330.00 | 10 | |
XMD8-92 is a small molecule inhibitor that specifically targets the MED12-MED13 protein-protein interaction. It disrupts the formation of the Mediator complex, leading to impaired transcriptional regulation. | ||||||