TPCN2 Inhibitors
TPCN2 inhibitors belong to a distinct chemical class characterized by their ability to modulate the activity of the two-pore channel 2 (TPCN2) protein. The TPCN2 protein, primarily located in the membranes of endo-lysosomal compartments within cells, plays a crucial role in the regulation of calcium ion transport across these membranes. The inhibitors exert their effects by selectively targeting and blocking the TPCN2 channels, thereby influencing the intracellular calcium homeostasis. Structurally, TPCN2 inhibitors often feature specific molecular motifs designed to interact with key residues within the TPCN2 protein, disrupting its function and impeding the transport of calcium ions across the endo-lysosomal membranes.
TPCN2 inhibitors lies in their potential to modulate cellular processes that are tightly regulated by calcium signaling. By interfering with TPCN2-mediated calcium transport, these inhibitors have the capacity to impact various cellular functions, including vesicle trafficking, autophagy, and endo-lysosomal fusion events. The development and study of TPCN2 inhibitors contribute to a deeper understanding of intracellular calcium dynamics and offer insights into the intricate regulatory mechanisms governing cellular processes.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Tetrandrine | 518-34-3 | sc-201492 sc-201492A | 100 mg 250 mg | $56.00 $100.00 | 9 | |
Tetrandrine is a calcium channel blocker that can inhibit the function of ion channels similar to TPCN2, leading to reduced channel permeability and altered intracellular calcium levels, which may affect TPCN2 activity. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $59.00 $173.00 | 15 | |
Nifedipine is known to block L-type calcium channels, which can influence the cellular processes that TPCN2 is involved in by altering calcium homeostasis, potentially reducing TPCN2 channel activity. | ||||||
Ruthenium red | 11103-72-3 | sc-202328 sc-202328A | 500 mg 1 g | $188.00 $250.00 | 13 | |
Ruthenium Red is a polycationic dye that can block several types of calcium channels and might interact with TPCN2, affecting its ion conductance. | ||||||
SK&F 96365 | 130495-35-1 | sc-201475 sc-201475B sc-201475A sc-201475C | 5 mg 10 mg 25 mg 50 mg | $103.00 $158.00 $397.00 $656.00 | 2 | |
SKF-96365 is an inhibitor of receptor-mediated calcium entry and store-operated channels; it can affect TPCN2-related pathways by modulating calcium signaling. | ||||||
2-APB | 524-95-8 | sc-201487 sc-201487A | 20 mg 100 mg | $28.00 $53.00 | 37 | |
2-APB is known to modulate store-operated calcium entry and could thus indirectly influence TPCN2 activity by altering calcium signaling in cells. | ||||||
Mibefradil dihydrochloride | 116666-63-8 | sc-204083 sc-204083A | 10 mg 50 mg | $213.00 $865.00 | 4 | |
Mibefradil is a T-type calcium channel blocker that can affect calcium signaling in a manner that may indirectly affect TPCN2 activity by altering ion conductance. | ||||||
CRAC Channel Inhibitor, BTP2 | 223499-30-7 | sc-221441 | 5 mg | $189.00 | 9 | |
BTP2, also known as YM58483, is a store-operated calcium entry inhibitor that can affect TPCN2 activity by modulating the calcium signaling pathways, which TPCN2 may be a part of. | ||||||
Gadolinium | 7440-54-2 | sc-250038 | 10 g | $89.00 | ||
Gadolinium ion is a blocker of various types of ion channels, including calcium channels, and could interact with TPCN2, potentially influencing its ion conductance. | ||||||
Econazole | 27220-47-9 | sc-279013 | 5 g | $240.00 | ||
Econazole is known to inhibit certain ion channels, and while it is primarily antifungal, it can affect calcium signaling, potentially altering TPCN2 channel function. | ||||||