Date published: 2026-5-30

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TMEM88 Inhibitors

TMEM88 inhibitors belong to a distinct chemical class renowned for their unique capacity to modulate the activity of transmembrane protein 88 (TMEM88). TMEM88 itself is a transmembrane protein whose functions and implications in cellular processes are still a subject of ongoing research. The inhibitors designed to target TMEM88 are characterized by their ability to selectively interact with this particular transmembrane protein, influencing its biological activity. The chemical structures of TMEM88 inhibitors are meticulously designed to ensure a high degree of specificity, minimizing off-target effects and interactions with other cellular components. Researchers employ various molecular design strategies to create these inhibitors, often focusing on understanding the three-dimensional structure of TMEM88 and optimizing the chemical entities that can bind to it with precision.

TMEM88 inhibitors involves their interaction with the target protein, modulating its function in cellular processes. The inhibition of TMEM88 may have downstream effects on signaling pathways or cellular functions, which can be explored in the context of basic research and elucidating the intricacies of cellular biology. Studying TMEM88 inhibitors provides a valuable tool for researchers to gain insights into the physiological roles of TMEM88 and its potential involvement in various cellular functions. As researchers delve deeper into the molecular and cellular consequences of TMEM88 inhibition, a more comprehensive understanding of this unique class of compounds and their impact on cellular processes is anticipated to emerge, potentially paving the way for future discoveries in the field of cell biology.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

IWP-2

686770-61-6sc-252928
sc-252928A
5 mg
25 mg
$96.00
$292.00
27
(1)

IWP-2 inhibits the production of Wnt proteins by blocking the activity of porcupine (PORCN), a membrane-bound O-acyltransferase, thus indirectly diminishing the Wnt signaling in which TMEM88 is involved.

XAV939

284028-89-3sc-296704
sc-296704A
sc-296704B
1 mg
5 mg
50 mg
$36.00
$117.00
$525.00
26
(1)

XAV-939 stabilizes Axin by inhibiting tankyrase, an enzyme involved in the regulation of β-catenin degradation, which is a core component of the Wnt signaling pathway.

LGK 974

1243244-14-5sc-489380
sc-489380A
5 mg
50 mg
$359.00
$1295.00
2
(0)

LGK-974 is a PORCN inhibitor like IWP-2, which also prevents the secretion and activity of Wnt ligands, thereby indirectly affecting TMEM88's influence through Wnt signaling.

JW 55

664993-53-7sc-364517
sc-364517A
10 mg
50 mg
$172.00
$726.00
(0)

JW 55 promotes the degradation of β-catenin, a key mediator of Wnt signaling, thereby indirectly impacting the signaling pathway involving TMEM88.

KY02111

1118807-13-8sc-397043
sc-397043A
5 mg
25 mg
$79.00
$336.00
(0)

KY02111 promotes the degradation of β-catenin by inhibiting Wnt signaling, which could indirectly reduce TMEM88's functional role in this pathway.

β-Catenin/Tcf Inhibitor, FH535

108409-83-2sc-221398
sc-221398A
10 mg
50 mg
$182.00
$374.00
7
(1)

FH535 is a dual inhibitor of β-catenin/TCF and PPAR signaling, potentially affecting the Wnt/β-catenin pathway and thereby indirectly the activity of TMEM88.

PNU-74654

113906-27-7sc-258020
sc-258020A
5 mg
25 mg
$131.00
$495.00
7
(2)

PNU-74654 disrupts the interaction between β-catenin and TCF, thus indirectly influencing TMEM88's role within the Wnt signaling pathway.

IWR-1-endo

1127442-82-3sc-295215
sc-295215A
5 mg
10 mg
$82.00
$135.00
19
(1)

IWR-1 destabilizes Axin2, leading to the inhibition of the Wnt/β-catenin signaling pathway, which can indirectly affect TMEM88's function.

Wnt Synergist, QS11

944328-88-5sc-222417
sc-222417A
5 mg
25 mg
$141.00
$607.00
(1)

QS11 inhibits GSK-3β induced phosphorylation of ARHGAP35, affecting actin dynamics and potentially Wnt signaling, which could indirectly affect TMEM88.

WIKI4

838818-26-1sc-397021
sc-397021A
5 mg
25 mg
$90.00
$351.00
(0)

WIKI4 inhibits the Wnt/β-catenin signaling pathway by stabilizing Axin1, which can indirectly impact TMEM88's functionality within this pathway.