TMEM177 Activators
Chemical activators of TMEM177 include a variety of compounds that influence different cellular signaling pathways. Forskolin is one such activator that works by stimulating adenylate cyclase, which in turn raises the intracellular levels of cyclic AMP (cAMP). This increase in cAMP levels leads to the activation of Protein Kinase A (PKA), a kinase that can phosphorylate TMEM177, potentially activating it as part of the cAMP signaling pathway. Similarly, Ionomycin raises intracellular calcium levels by acting as a calcium ionophore. The surge in calcium ions can activate calmodulin-dependent kinases, which are known to phosphorylate various proteins, including TMEM177, thereby integrating it into calcium-dependent signaling pathways.
On the other hand, Phorbol 12-myristate 13-acetate (PMA) engages with protein kinase C (PKC), which upon activation, phosphorylates a range of proteins. PKC-mediated phosphorylation can encompass TMEM177, integrating it into PKC-related signaling. Hydrogen Peroxide, as a reactive oxygen species, can activate Mitogen-Activated Protein Kinases (MAPKs), which may phosphorylate TMEM177 in response to oxidative signals. Sodium Orthovanadate, by inhibiting tyrosine phosphatases, may also preserve TMEM177 in a phosphorylated state, while Okadaic Acid, a protein phosphatase inhibitor, can enhance the phosphorylation state of TMEM177, leading to its sustained activation. Additionally, Anisomycin activates the stress-activated protein kinases such as JNK, which might phosphorylate and thereby activate TMEM177 as part of the cellular stress response. This assortment of chemicals demonstrates the diverse molecular mechanisms through which TMEM177 can be activated, each engaging with distinct signaling pathways and cellular processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, leading to an increase in cAMP levels. Elevated cAMP activates PKA (Protein Kinase A), which may phosphorylate and activate TMEM177 as part of downstream signaling. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels. This surge in calcium can activate calmodulin-dependent kinases, which could phosphorylate and activate TMEM177 within calcium-dependent signaling pathways. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC). PKC, upon activation, is known to phosphorylate a wide range of proteins. This phosphorylation can extend to TMEM177, leading to its activation within PKC-regulated pathways. | ||||||
(±)-S-Nitroso-N-acetylpenicillamine | 79032-48-7 | sc-200319B sc-200319 sc-200319A | 10 mg 20 mg 100 mg | $73.00 $112.00 $367.00 | 18 | |
SNAP releases nitric oxide, which can activate soluble guanylate cyclase, increasing cGMP levels. Elevated cGMP can activate PKG (Protein Kinase G), which may phosphorylate and activate TMEM177 as part of NO/cGMP signaling pathways. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $30.00 $60.00 $93.00 | 27 | |
Hydrogen peroxide serves as a reactive oxygen species that can modulate signaling pathways through oxidative stress. It can activate MAPKs (Mitogen-Activated Protein Kinases), which may directly phosphorylate and activate TMEM177 in response to oxidative signals. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc ions, provided by zinc sulfate, can act as a second messenger or structural element in various proteins. They could stabilize the conformation of TMEM177 or associated proteins in a way that promotes its activation within zinc-mediated signaling pathways. | ||||||
Sodium Orthovanadate | 13721-39-6 | sc-3540 sc-3540B sc-3540A | 5 g 10 g 50 g | $45.00 $56.00 $183.00 | 142 | |
Sodium orthovanadate is an inhibitor of tyrosine phosphatases. By inhibiting dephosphorylation, it may maintain TMEM177 in a phosphorylated and active state within tyrosine kinase signaling pathways. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $60.00 $270.00 $350.00 | 48 | |
AICAR is an activator of AMP-activated protein kinase (AMPK). AMPK activation can lead to the phosphorylation and subsequent activation of TMEM177 as part of the cellular energy balance and metabolic signaling. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic acid is a potent inhibitor of protein phosphatases 1 and 2A, leading to increased phosphorylation levels of proteins. This inhibition can result in the sustained phosphorylation and activation of TMEM177 within pathways regulated by these phosphatases. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is known to activate stress-activated protein kinases such as JNK (c-Jun N-terminal kinase). JNK activation can lead to phosphorylation and activation of TMEM177 as part of the cellular response to stress. | ||||||