TMEM170 Activators

Forskolin stands out as it directly stimulates adenylate cyclase, causing an increase in cAMP levels, which can lead to the activation of PKA; a kinase likely to phosphorylate downstream proteins associated with TMEM170. IBMX complements this by inhibiting the breakdown of cAMP, amplifying the signaling effects that might affect TMEM170. PMA activates PKC, initiating phosphorylation events, while kinase inhibitors like Staurosporine and Gö 6983 adjust the phosphorylation state of proteins within TMEM170-related pathways.

Calcium signaling modifiers such as U73122, W-7 Hydrochloride, and KN-93 influence phospholipase C, calmodulin, and Ca2+/calmodulin-dependent protein kinases, respectively, hinting at their potential to intersect with TMEM170-mediated pathways due to the role of calcium in cellular signaling. Genistein inhibits tyrosine kinases, which could lead to alterations in TMEM170-associated pathways. Similarly, LY294002 and PD98059 target the PI3K/Akt and MAPK/ERK pathways, central conduits for numerous cellular responses, potentially affecting TMEM170.