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TLR2 Activators

TLR2 Activators, as a chemical class, target this receptor to initiate or modulate the aforementioned signaling cascades. These compounds may mimic the PAMPs and DAMPs that TLR2 naturally recognizes, or they may bind to specific sites on the receptor to induce a conformational change, triggering activation. Some common TLR2 activators include synthetic lipopeptides and lipopolysaccharides, which closely resemble the molecular structures that TLR2 naturally identifies. Furthermore, TLR2 activators may also influence the receptor's interaction with its co-receptors and adaptor proteins, thereby modulating the entire signaling pathway. TLR2 activators have the ability to significantly shape immune responses by influencing the expression of genes involved in inflammation, cell recruitment, and overall immune system activation. Understanding the chemistry and mechanism of TLR2 activators is crucial for a more comprehensive grasp of innate immune modulation.TLR2 (Toll-like receptor 2) is a protein that plays a pivotal role in the innate immune system. This membrane-bound receptor is commonly found on immune cells such as macrophages and dendritic cells. It serves as a primary sensor for detecting pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs), which are often found on microbes and damaged host cells. When TLR2 identifies these specific molecular structures, it sets off a cascade of intracellular signaling events, ultimately resulting in the activation of various transcription factors like NF-κB. The activation of these pathways leads to the production of cytokines and chemokines, modulating the immune response and facilitating the clearance of pathogens or damaged cells.

Product Name	CAS #	Catalog #	QUANTITY	Price	Citations	RATING
Pam3Cys-Ser-(Lys)4 trihydrochloride	112208-04-5	sc-202271	2 mg	$423.00		(1)
Pam3Cys-Ser-(Lys)4 trihydrochloride is a synthetic lipopeptide that selectively activates TLR2, facilitating the recognition of pathogen-associated molecular patterns. Its unique amphiphilic nature promotes membrane interaction, enhancing receptor clustering and subsequent signal transduction. The compound's structural motifs enable specific interactions with TLR2, leading to the modulation of cytokine production and immune cell activation. This specificity and stability contribute to its dynamic role in immune modulation.
Pam3Cys-Ser-(Lys)4, Hydrochloride	112208-00-1	sc-507471	2 mg	$550.00		(0)
Binds directly to TLR2/TLR1, leading to receptor dimerization and signaling activation.
FSL-1	322455-70-9	sc-396677	100 µg	$250.00	3	(1)
FSL-1 is a synthetic lipopeptide that engages TLR2, triggering a cascade of immune responses. Its unique lipid tail enhances membrane affinity, promoting receptor oligomerization and efficient downstream signaling. The compound's structural features allow for precise binding to TLR2, influencing the activation of various intracellular pathways. This interaction leads to the production of pro-inflammatory cytokines, underscoring its role in shaping immune responses.
(R)-FSL-1		sc-396679	100 µg	$370.00		(0)
(R)-FSL-1 is a synthetic lipopeptide that selectively activates TLR2, initiating a robust immune signaling cascade. Its unique amphiphilic structure facilitates strong interactions with lipid membranes, enhancing receptor clustering and subsequent activation. The compound's specific conformation allows for optimal engagement with TLR2, influencing downstream signaling pathways and modulating the expression of key immune mediators. This precise interaction underscores its role in immune modulation.
Polyinosinic acid - polycytidylic acid sodium salt, double-stranded	42424-50-0	sc-204854 sc-204854A	10 mg 100 mg	$139.00 $650.00	2	(1)
Indirectly activates TLR2 by initially stimulating TLR3.
Imiquimod	99011-02-6	sc-200385 sc-200385A	100 mg 500 mg	$66.00 $278.00	6	(1)
Indirectly affects TLR2 by mainly targeting TLR7.
R-848	144875-48-9	sc-203231 sc-203231A sc-203231B sc-203231C	5 mg 25 mg 100 mg 500 mg	$100.00 $300.00 $500.00 $1528.00	12	(1)
Affects TLR2 signaling indirectly by being a TLR7/TLR8 agonist.

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TLR2 Activators

Pam3Cys-Ser-(Lys)4 trihydrochloride

Pam3Cys-Ser-(Lys)4, Hydrochloride

FSL-1

(R)-FSL-1

Polyinosinic acid - polycytidylic acid sodium salt, double-stranded

Imiquimod

R-848